diff --git a/UV-req-lock.txt b/UV-req-lock.txt
new file mode 100644
index 000000000..8cf3abeb0
--- /dev/null
+++ b/UV-req-lock.txt
@@ -0,0 +1,2 @@
+pip==24.0
+setuptools==65.5.0
diff --git a/clean_venv.py b/clean_venv.py
new file mode 100755
index 000000000..e6e89ab1f
--- /dev/null
+++ b/clean_venv.py
@@ -0,0 +1,111 @@
+#!/usr/bin/env python3
+"""
+ComfyUI Virtual Environment Cleanup Script
+Created: May 2, 2025
+"""
+
+import argparse
+import os
+import shutil
+import sys
+import platform
+from pathlib import Path
+
+def deactivate_venv():
+    """Attempt to deactivate any active virtual environment."""
+    if "VIRTUAL_ENV" in os.environ:
+        print(f"Active virtual environment detected: {os.environ['VIRTUAL_ENV']}")
+        print("Attempting to deactivate...")
+        
+        # This won't actually deactivate within this process since Python can't modify
+        # its parent environment, but it will provide instructions to the user
+        print("\nTo properly deactivate your virtual environment, please run:")
+        if platform.system() == "Windows":
+            print("    deactivate")
+        else:
+            print("    deactivate")
+        
+        print("\nAfter deactivating, run this script again.")
+        return True
+    return False
+
+def remove_venv(venv_path, force=False):
+    """Remove a virtual environment directory if it exists."""
+    path = Path(venv_path).expanduser().resolve()
+    
+    if not path.exists():
+        print(f"Virtual environment not found at: {path}")
+        return False
+    
+    # Safety check - make sure it looks like a venv
+    is_venv = False
+    if platform.system() == "Windows":
+        is_venv = (path / "Scripts" / "python.exe").exists()
+    else:
+        is_venv = (path / "bin" / "python").exists()
+    
+    if not is_venv and not force:
+        print(f"Warning: {path} doesn't appear to be a virtual environment.")
+        print("Use --force to remove it anyway.")
+        return False
+    
+    try:
+        print(f"Removing virtual environment at: {path}")
+        shutil.rmtree(path)
+        print("✅ Virtual environment removed successfully.")
+        return True
+    except Exception as e:
+        print(f"❌ Error removing virtual environment: {e}")
+        if platform.system() == "Windows":
+            print("\nTry running this script with administrator privileges or closing any")
+            print("applications that might be using files in the virtual environment.")
+        else:
+            print("\nTry running this script with sudo if you have permission issues:")
+            print(f"    sudo rm -rf {path}")
+        return False
+
+def main():
+    parser = argparse.ArgumentParser(description="Remove ComfyUI virtual environments")
+    parser.add_argument("--all", action="store_true", help="Remove all known virtual environment locations")
+    parser.add_argument("--force", action="store_true", help="Force removal even if directory doesn't look like a venv")
+    parser.add_argument("--venv-path", type=str, help="Path to custom virtual environment to remove")
+    args = parser.parse_args()
+    
+    # Don't proceed if a virtual environment is active
+    if deactivate_venv():
+        return
+    
+    # Common venv locations
+    venv_locations = [
+        ".venv",                  # Default UV venv name
+        "venv",                   # Common alternative name
+        Path.home() / ".venvs" / "comfyui",  # User-level venvs
+    ]
+    
+    if args.venv_path:
+        # Just remove the specified venv
+        remove_venv(args.venv_path, args.force)
+    elif args.all:
+        # Remove all common venv locations
+        removed_any = False
+        for venv_loc in venv_locations:
+            if remove_venv(venv_loc, args.force):
+                removed_any = True
+        
+        if not removed_any:
+            print("No virtual environments were found in common locations.")
+    else:
+        # Default: just remove .venv
+        if not remove_venv(".venv", args.force):
+            print("\nTo remove other virtual environment locations, use:")
+            print("    python clean_venv.py --all")
+            print("    python clean_venv.py --venv-path /path/to/venv")
+    
+    print("\n🚀 Ready to create a new UV-based environment!")
+    print("Run the following commands to set up with UV:")
+    print("    ./uv_setup.sh")
+    print("    source .venv/bin/activate  # On Linux/macOS")
+    print("    ./update_dependencies_uv.py --advanced --cuda --lock")
+
+if __name__ == "__main__":
+    main()
\ No newline at end of file
diff --git a/pyproject.toml b/pyproject.toml
index 97420defc..5361562a0 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -34,4 +34,26 @@ lint.select = [
 exclude = ["*.ipynb"]
 
 [tool.uv]
-# Add any uv-specific configurations here
+# UV-specific configurations (updated May 2025)
+python = "3.11"
+system = false
+verbosity = 1
+threads = "auto"
+no-binary = []
+only-binary = []
+
+[tool.uv.dependencies]
+# Core dependencies with modern 2025 versions
+torch = { version = ">=2.3.0", source = "pytorch" }
+torchvision = { version = ">=0.18.0", source = "pytorch" }
+numpy = ">=2.0.0"
+pillow = ">=10.0.0"
+aiohttp = ">=3.9.0"
+rich = ">=13.6.0"
+tqdm = ">=4.66.0"
+transformers = ">=4.38.0"
+diffusers = ">=0.25.0"
+safetensors = ">=0.4.0"
+
+[tool.uv.sources]
+pytorch = { url = "https://download.pytorch.org/whl/cu121" }
diff --git a/requirements.txt b/requirements.txt
index 74a4ceb02..bec554918 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -17,6 +17,18 @@ Pillow
 scipy
 tqdm
 psutil
+opencv-python>=4.8.0
+flash-attn>=2.3.0
+nvidia-cuda-runtime-cu12>=12.0.0
+nvidia-cuda-nvrtc-cu12>=12.0.0
+nvidia-cudnn-cu12>=8.9.0
+nvidia-cublas-cu12>=12.0.0
+nvidia-cufft-cu12>=11.0.0
+nvidia-curand-cu12>=10.3.0
+nvidia-cusolver-cu12>=11.4.0
+nvidia-cusparse-cu12>=12.1.0
+nvidia-nccl-cu12>=2.18.0
+nvidia-nvtx-cu12>=12.0.0
 
 #non essential dependencies:
 kornia>=0.7.1
diff --git a/update_dependencies_uv.py b/update_dependencies_uv.py
new file mode 100755
index 000000000..d488bc66b
--- /dev/null
+++ b/update_dependencies_uv.py
@@ -0,0 +1,104 @@
+#!/usr/bin/env python3
+"""
+ComfyUI Dependency Update Script using UV
+Created: May 2, 2025
+"""
+
+import argparse
+import os
+import platform
+import subprocess
+import sys
+
+def check_uv_installed():
+    """Check if UV is installed and install if missing."""
+    try:
+        subprocess.run(["uv", "--version"], stdout=subprocess.PIPE, stderr=subprocess.PIPE, check=True)
+        print("✅ UV is installed")
+        return True
+    except (subprocess.CalledProcessError, FileNotFoundError):
+        print("⚠️ UV not found. Installing...")
+        
+        if platform.system() == "Windows":
+            subprocess.run(
+                ["powershell", "-Command", "Invoke-WebRequest -Uri https://astral.sh/uv/install.ps1 -OutFile install.ps1; ./install.ps1"],
+                check=True
+            )
+        else:
+            subprocess.run(
+                ["bash", "-c", "curl -LsSf https://astral.sh/uv/install.sh | sh"],
+                check=True
+            )
+        
+        print("✅ UV installed successfully")
+        return True
+
+def update_dependencies(args):
+    """Update dependencies using UV."""
+    # Ensure we're in a virtual environment
+    if not os.environ.get("VIRTUAL_ENV") and not args.no_venv_check:
+        print("⚠️ Not running in a virtual environment. Activate one before updating dependencies.")
+        print("💡 Run: uv venv && source .venv/bin/activate (or .venv\\Scripts\\activate on Windows)")
+        if not args.force:
+            return False
+    
+    print("📦 Updating dependencies using UV...")
+    
+    # Update base requirements
+    subprocess.run(["uv", "pip", "install", "--upgrade", "-r", "requirements.txt"], check=True)
+    print("✅ Base dependencies updated")
+    
+    # Update advanced requirements if requested
+    if args.advanced:
+        subprocess.run(["uv", "pip", "install", "--upgrade", "-r", "requirements_advanced.txt"], check=True)
+        print("✅ Advanced dependencies updated")
+    
+    # Update PyTorch with CUDA if requested
+    if args.cuda:
+        torch_version = "2.4.0" if args.latest else "2.3.0"
+        cuda_version = "12.1" if args.latest else "11.8"
+        
+        print(f"🔄 Installing PyTorch {torch_version} with CUDA {cuda_version}...")
+        subprocess.run([
+            "uv", "pip", "install", "--upgrade", 
+            f"torch=={torch_version}", 
+            f"torchvision>={torch_version}", 
+            f"torchaudio>={torch_version}", 
+            "--index-url", f"https://download.pytorch.org/whl/cu{cuda_version.replace('.', '')}"
+        ], check=True)
+        print("✅ PyTorch updated with CUDA support")
+    
+    # Generate lockfile for reproducibility
+    if args.lock:
+        print("🔒 Generating lockfile...")
+        subprocess.run(["uv", "pip", "freeze", ">", "UV-req-lock.txt"], shell=True, check=True)
+        print("✅ Lockfile generated: UV-req-lock.txt")
+    
+    return True
+
+def main():
+    parser = argparse.ArgumentParser(description="Update ComfyUI dependencies using UV")
+    parser.add_argument("--advanced", action="store_true", help="Update advanced dependencies")
+    parser.add_argument("--cuda", action="store_true", help="Update PyTorch with CUDA support")
+    parser.add_argument("--latest", action="store_true", help="Use latest versions (may be less stable)")
+    parser.add_argument("--lock", action="store_true", help="Generate lockfile after update")
+    parser.add_argument("--force", action="store_true", help="Force update even if not in venv")
+    parser.add_argument("--no-venv-check", action="store_true", help="Skip virtual environment check")
+    
+    args = parser.parse_args()
+    
+    print("ComfyUI Dependency Update")
+    print("========================")
+    
+    if not check_uv_installed():
+        sys.exit(1)
+    
+    if update_dependencies(args):
+        print("\n✨ Dependencies updated successfully!")
+        print("\n💡 To start ComfyUI, run: python main.py")
+    else:
+        print("\n❌ Dependency update failed or was skipped")
+        sys.exit(1)
+
+if __name__ == "__main__":
+    main()
\ No newline at end of file
diff --git a/uv_setup.sh b/uv_setup.sh
new file mode 100755
index 000000000..193d45044
--- /dev/null
+++ b/uv_setup.sh
@@ -0,0 +1,45 @@
+#!/bin/bash
+# ComfyUI UV Environment Setup Script
+# Created: May 2, 2025
+
+# Set UV environment variables for better performance
+export UV_CACHE_DIR="${HOME}/.cache/uv"
+export UV_SYSTEM_PYTHON=false
+export UV_DEFAULT_PYTHON=3.11
+export UV_THREADS=auto
+export UV_VERBOSITY=1
+
+# Create directory structure if needed
+mkdir -p "${UV_CACHE_DIR}"
+
+echo "UV environment variables set:"
+echo "  UV_CACHE_DIR: ${UV_CACHE_DIR}"
+echo "  UV_DEFAULT_PYTHON: ${UV_DEFAULT_PYTHON}"
+echo "  UV_THREADS: ${UV_THREADS}"
+
+# Check if UV is installed
+if ! command -v uv >/dev/null 2>&1; then
+    echo "UV not found. Installing..."
+    curl -LsSf https://astral.sh/uv/install.sh | sh
+    
+    # Add to PATH for this session
+    source $HOME/.local/bin/env
+fi
+
+# Check for ComfyUI virtual environment
+if [ ! -d ".venv" ]; then
+    echo "Creating virtual environment..."
+    uv venv
+    echo "Virtual environment created at .venv"
+fi
+
+echo ""
+echo "To activate the virtual environment, run:"
+echo "  source .venv/bin/activate     # On Linux/macOS"
+echo "  .venv\\Scripts\\activate.bat  # On Windows"
+echo ""
+echo "To install/update dependencies:"
+echo "  ./update_dependencies_uv.py --advanced --cuda --lock"
+echo ""
+echo "To start ComfyUI:"
+echo "  python main.py"
\ No newline at end of file