diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X.json
index 66f9106bd1be3..4bf775347eccb 100644
--- a/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X.json
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X.json
@@ -45,8 +45,8 @@
     },
     "16": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 16,
-        "BLOCK_SIZE_K": 256,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
         "GROUP_SIZE_M": 1,
         "num_warps": 2,
         "num_stages": 2,
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X.json
index ed5b655d89937..5a3f415d54142 100644
--- a/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X.json
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X.json
@@ -45,8 +45,8 @@
     },
     "16": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 256,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 1,
         "num_warps": 2,
         "num_stages": 2,
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X.json
index 822f04e33e879..8d7b780271854 100644
--- a/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X.json
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X.json
@@ -128,7 +128,7 @@
         "num_warps": 8,
         "num_stages": 2,
         "waves_per_eu": 0,
-        "matrix_instr_nonkdim": 32,
+        "matrix_instr_nonkdim": 16,
         "kpack": 2
     },
     "512": {