diff --git a/vllm/v1/attention/backends/flashinfer.py b/vllm/v1/attention/backends/flashinfer.py
index 623ae892ecdaf..527da03594a7c 100755
--- a/vllm/v1/attention/backends/flashinfer.py
+++ b/vllm/v1/attention/backends/flashinfer.py
@@ -718,6 +718,22 @@ class FlashInferMetadataBuilder(AttentionMetadataBuilder[FlashInferMetadata]):
             )
         return self._cascade_wrapper
 
+    @override
+    def reset_after_sleep(self) -> None:
+        """
+        Reset FlashInfer wrappers after sleep mode.
+
+        FlashInfer wrappers cache internal buffers that may be freed during
+        sleep mode. By resetting them to None, they will be lazily recreated
+        with fresh buffers on next use.
+        """
+        self._workspace_buffer = None
+        self._prefill_wrapper = None
+        self._decode_wrapper = None
+        self._cascade_wrapper = None
+        if self.enable_cuda_graph:
+            self._decode_wrappers_cudagraph.clear()
+
     def _compute_flashinfer_kv_metadata(
         self,
         num_blocks_np: np.ndarray,
diff --git a/vllm/v1/attention/backends/utils.py b/vllm/v1/attention/backends/utils.py
index 6b94f786a26b2..bc56c84577920 100644
--- a/vllm/v1/attention/backends/utils.py
+++ b/vllm/v1/attention/backends/utils.py
@@ -454,6 +454,20 @@ class AttentionMetadataBuilder(abc.ABC, Generic[M]):
     ) -> bool:
         return False
 
+    def reset_after_sleep(self) -> None:
+        """
+        Reset internal state after sleep mode.
+
+        Some attention backends cache internal buffers (e.g., FlashInfer
+        wrappers) that may be freed during sleep mode. This method should
+        be called after wake_up to invalidate those caches so they get
+        recreated with fresh buffers on next use.
+
+        By default, this is a no-op. Backends that cache stateful objects
+        should override this method.
+        """
+        pass
+
 
 @functools.lru_cache
 def get_kv_cache_layout():
diff --git a/vllm/v1/worker/gpu_worker.py b/vllm/v1/worker/gpu_worker.py
index 68fe0853370f7..0b6d214e5d28d 100644
--- a/vllm/v1/worker/gpu_worker.py
+++ b/vllm/v1/worker/gpu_worker.py
@@ -161,6 +161,25 @@ class Worker(WorkerBase):
         ):
             self.model_runner.init_fp8_kv_scales()
 
+        # Reset attention backend internal state after sleep.
+        # Some backends (e.g., FlashInfer) cache internal buffers that may be
+        # freed during sleep mode and need to be recreated on wake_up.
+        if tags is None or "kv_cache" in tags:
+            self._reset_attention_backends_after_sleep()
+
+    def _reset_attention_backends_after_sleep(self) -> None:
+        """Reset attention backends after sleep mode.
+
+        Iterates through all attention groups and calls reset_after_sleep()
+        on each metadata builder to invalidate cached internal state.
+        """
+        if not hasattr(self.model_runner, "attn_groups"):
+            return
+        for kv_cache_group in self.model_runner.attn_groups:
+            for attn_group in kv_cache_group:
+                for builder in attn_group.metadata_builders:
+                    builder.reset_after_sleep()
+
     def _maybe_get_memory_pool_context(self, tag: str) -> AbstractContextManager:
         if self.vllm_config.model_config.enable_sleep_mode:
             from vllm.device_allocator.cumem import CuMemAllocator