diff --git a/.buildkite/scripts/hardware_ci/run-npu-test.sh b/.buildkite/scripts/hardware_ci/run-npu-test.sh
new file mode 100644
index 0000000000000..29c8f5ed5a91a
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+++ b/.buildkite/scripts/hardware_ci/run-npu-test.sh
@@ -0,0 +1,191 @@
+#!/bin/bash
+
+# This script build the Ascend NPU docker image and run the offline inference inside the container.
+# It serves a sanity check for compilation and basic model usage.
+set -ex
+
+# Base ubuntu image with basic ascend development libraries and python installed
+VLLM_ASCEND_REPO="https://github.com/vllm-project/vllm-ascend.git"
+CONFIG_FILE_REMOTE_PATH="tests/e2e/vllm_interface/vllm_test.cfg"
+TEST_RUN_CONFIG_FILE="vllm_test.cfg"
+VLLM_ASCEND_TMP_DIR=
+# Get the test run configuration file from the vllm-ascend repository
+fetch_vllm_test_cfg() {
+    VLLM_ASCEND_TMP_DIR=$(mktemp -d)
+    # Ensure that the temporary directory is cleaned up when an exception occurs during configuration file retrieval
+    cleanup() {
+        rm -rf "${VLLM_ASCEND_TMP_DIR}"
+    }
+    trap cleanup EXIT
+
+    GIT_TRACE=1 git clone -v --depth 1 "${VLLM_ASCEND_REPO}" "${VLLM_ASCEND_TMP_DIR}"
+    if [ ! -f "${VLLM_ASCEND_TMP_DIR}/${CONFIG_FILE_REMOTE_PATH}" ]; then
+        echo "Error: file '${CONFIG_FILE_REMOTE_PATH}' does not exist in the warehouse" >&2
+        exit 1
+    fi
+
+    # If the file already exists locally, just overwrite it
+    cp "${VLLM_ASCEND_TMP_DIR}/${CONFIG_FILE_REMOTE_PATH}" "${TEST_RUN_CONFIG_FILE}"
+    echo "Copied ${CONFIG_FILE_REMOTE_PATH} to ${TEST_RUN_CONFIG_FILE}"
+
+    # Since the trap will be overwritten later, and when it is executed here, the task of cleaning up resources
+    # when the trap is abnormal has been completed, so the temporary resources are manually deleted here.
+    rm -rf "${VLLM_ASCEND_TMP_DIR}"
+    trap - EXIT
+}
+
+# Downloads test run configuration file from a remote URL.
+# Loads the configuration into the current script environment.
+get_config() {
+    if [ ! -f "${TEST_RUN_CONFIG_FILE}" ]; then
+        echo "Error: file '${TEST_RUN_CONFIG_FILE}' does not exist in the warehouse" >&2
+        exit 1
+    fi
+    source "${TEST_RUN_CONFIG_FILE}"
+    echo "Base docker image name that get from configuration: ${BASE_IMAGE_NAME}"
+    return 0
+}
+
+# get test running configuration.
+fetch_vllm_test_cfg
+get_config
+# Check if the function call was successful. If not, exit the script.
+if [ $? -ne 0 ]; then
+  exit 1
+fi
+
+image_name="npu/vllm-ci:${BUILDKITE_COMMIT}_${EPOCHSECONDS}"
+container_name="npu_${BUILDKITE_COMMIT}_$(tr -dc A-Za-z0-9 < /dev/urandom | head -c 10; echo)"
+
+# BUILDKITE_AGENT_NAME format is {hostname}-{agent_idx}-{npu_card_num}cards
+agent_idx=$(echo "${BUILDKITE_AGENT_NAME}" | awk -F'-' '{print $(NF-1)}')
+echo "agent_idx: ${agent_idx}"
+builder_name="cachebuilder${agent_idx}"
+builder_cache_dir="/mnt/docker-cache${agent_idx}"
+mkdir -p ${builder_cache_dir}
+
+# Try building the docker image
+cat <<EOF | DOCKER_BUILDKIT=1 docker build \
+    --add-host cache-service-vllm.nginx-pypi-cache.svc.cluster.local:${PYPI_CACHE_HOST} \
+    --builder ${builder_name} --cache-from type=local,src=${builder_cache_dir} \
+                           --cache-to type=local,dest=${builder_cache_dir},mode=max \
+    --progress=plain --load -t ${image_name} -f - .
+FROM ${BASE_IMAGE_NAME}
+
+# Define environments
+ENV DEBIAN_FRONTEND=noninteractive
+
+RUN pip config set global.index-url http://cache-service-vllm.nginx-pypi-cache.svc.cluster.local:${PYPI_CACHE_PORT}/pypi/simple && \
+    pip config set global.trusted-host cache-service-vllm.nginx-pypi-cache.svc.cluster.local && \
+    apt-get update -y && \
+    apt-get install -y python3-pip git vim wget net-tools gcc g++ cmake libnuma-dev && \
+    rm -rf /var/cache/apt/* && \
+    rm -rf /var/lib/apt/lists/*
+
+# Install for pytest to make the docker build cache layer always valid
+RUN --mount=type=cache,target=/root/.cache/pip \
+    pip install pytest>=6.0  modelscope
+
+WORKDIR /workspace/vllm
+
+# Install vLLM dependencies in advance. Effect: As long as common.txt remains unchanged, the docker cache layer will be valid.
+COPY requirements/common.txt /workspace/vllm/requirements/common.txt
+RUN --mount=type=cache,target=/root/.cache/pip \
+    pip install -r requirements/common.txt
+
+COPY . .
+
+# Install vLLM
+RUN --mount=type=cache,target=/root/.cache/pip \
+    VLLM_TARGET_DEVICE="empty" python3 -m pip install -v -e /workspace/vllm/ --extra-index https://download.pytorch.org/whl/cpu/ && \
+    python3 -m pip uninstall -y triton
+
+# Install vllm-ascend
+WORKDIR /workspace
+ARG VLLM_ASCEND_REPO=https://github.com/vllm-project/vllm-ascend.git
+ARG VLLM_ASCEND_TAG=main
+RUN git config --global url."https://gh-proxy.test.osinfra.cn/https://github.com/".insteadOf "https://github.com/" && \
+    git clone --depth 1 \$VLLM_ASCEND_REPO --branch \$VLLM_ASCEND_TAG /workspace/vllm-ascend
+
+# Install vllm dependencies in advance. Effect: As long as common.txt remains unchanged, the docker cache layer will be valid.
+RUN --mount=type=cache,target=/root/.cache/pip \
+    pip install -r /workspace/vllm-ascend/requirements.txt
+
+RUN --mount=type=cache,target=/root/.cache/pip \
+    export PIP_EXTRA_INDEX_URL=https://mirrors.huaweicloud.com/ascend/repos/pypi && \
+    source /usr/local/Ascend/ascend-toolkit/set_env.sh && \
+    source /usr/local/Ascend/nnal/atb/set_env.sh && \
+    export LD_LIBRARY_PATH=\$LD_LIBRARY_PATH:/usr/local/Ascend/ascend-toolkit/latest/`uname -i`-linux/devlib && \
+    python3 -m pip install -v -e /workspace/vllm-ascend/ --extra-index https://download.pytorch.org/whl/cpu/
+
+ENV VLLM_WORKER_MULTIPROC_METHOD=spawn
+ENV VLLM_USE_MODELSCOPE=True
+
+WORKDIR /workspace/vllm-ascend
+
+CMD ["/bin/bash"]
+
+EOF
+
+# Setup cleanup
+remove_docker_container() {
+  docker rm -f "${container_name}" || true;
+  docker image rm -f "${image_name}" || true;
+  docker system prune -f || true;
+}
+trap remove_docker_container EXIT
+
+# Generate corresponding --device args based on BUILDKITE_AGENT_NAME
+# Ascend NPU BUILDKITE_AGENT_NAME format is {hostname}-{agent_idx}-{npu_card_num}cards, and agent_idx starts from 1.
+#   e.g. atlas-a2-001-1-2cards means this is the 1-th agent on atlas-a2-001 host, and it has 2 NPU cards.
+#   returns --device /dev/davinci0 --device /dev/davinci1
+parse_and_gen_devices() {
+    local input="$1"
+    local index cards_num
+    if [[ "$input" =~ ([0-9]+)-([0-9]+)cards$ ]]; then
+        index="${BASH_REMATCH[1]}"
+        cards_num="${BASH_REMATCH[2]}"
+    else
+        echo "parse error" >&2
+        return 1
+    fi
+
+    local devices=""
+    local i=0
+    while (( i < cards_num )); do
+        local dev_idx=$(((index - 1)*cards_num + i ))
+        devices="$devices --device /dev/davinci${dev_idx}"
+        ((i++))
+    done
+
+    # trim leading space
+    devices="${devices#"${devices%%[![:space:]]*}"}"
+    # Output devices: assigned to the caller variable
+    printf '%s' "$devices"
+}
+
+devices=$(parse_and_gen_devices "${BUILDKITE_AGENT_NAME}") || exit 1
+
+# Run the image and execute the Out-Of-Tree (OOT) platform interface test case on Ascend NPU hardware.
+# This test checks whether the OOT platform interface is functioning properly in conjunction with
+# the hardware plugin vllm-ascend.
+model_cache_dir=/mnt/modelscope${agent_idx}
+mkdir -p ${model_cache_dir}
+docker run \
+    ${devices} \
+    --device /dev/davinci_manager \
+    --device /dev/devmm_svm \
+    --device /dev/hisi_hdc \
+    -v /usr/local/dcmi:/usr/local/dcmi \
+    -v /usr/local/bin/npu-smi:/usr/local/bin/npu-smi \
+    -v /usr/local/Ascend/driver/lib64/:/usr/local/Ascend/driver/lib64/ \
+    -v /usr/local/Ascend/driver/version.info:/usr/local/Ascend/driver/version.info \
+    -v /etc/ascend_install.info:/etc/ascend_install.info \
+    -v ${model_cache_dir}:/root/.cache/modelscope \
+    --entrypoint="" \
+    --name "${container_name}" \
+    "${image_name}" \
+    bash -c '
+    set -e
+    pytest -v -s tests/e2e/vllm_interface/
+'