diff --git a/tests/v1/kv_connector/unit/test_offloading_connector.py b/tests/v1/kv_connector/unit/test_offloading_connector.py
index 23b6c4802d106..69565f584ab89 100644
--- a/tests/v1/kv_connector/unit/test_offloading_connector.py
+++ b/tests/v1/kv_connector/unit/test_offloading_connector.py
@@ -19,6 +19,7 @@ from vllm.distributed.kv_transfer.kv_connector.v1.offloading_connector import (
 )
 from vllm.forward_context import ForwardContext
 from vllm.utils.hashing import sha256
+from vllm.v1.attention.backends.flash_attn import FlashAttentionBackend
 from vllm.v1.core.kv_cache_utils import (
     BlockHash,
     get_request_block_hasher,
@@ -92,7 +93,7 @@ class MockOffloadingSpec(OffloadingSpec):
         return self.manager
 
     def get_handlers(
-        self, _
+        self, _, __
     ) -> Iterator[tuple[type[LoadStoreSpec], type[LoadStoreSpec], OffloadingHandler]]:
         yield GPULoadStoreSpec, MockLoadStoreSpec, self.handler
         yield MockLoadStoreSpec, GPULoadStoreSpec, self.handler
@@ -138,7 +139,10 @@ class RequestRunner:
         self.worker_connector = OffloadingConnector(vllm_config, KVConnectorRole.WORKER)
 
         # register worker kv_caches to enable OffloadingWorker creations
-        self.worker_connector.register_kv_caches(kv_caches={"a": torch.empty(0)})
+        self.worker_connector.register_cross_layers_kv_cache(
+            kv_cache=torch.empty(0),
+            attn_backend=FlashAttentionBackend,
+        )
 
         # extract connector of scheduler
         scheduler_connector = self.scheduler.connector
diff --git a/tests/v1/kv_offload/test_cpu_offloading.py b/tests/v1/kv_offload/test_cpu_offloading.py
index b654ea4298dbb..3ee41c40859dc 100644
--- a/tests/v1/kv_offload/test_cpu_offloading.py
+++ b/tests/v1/kv_offload/test_cpu_offloading.py
@@ -12,8 +12,10 @@ from tqdm import tqdm
 from vllm import LLM, SamplingParams, TokensPrompt
 from vllm.config import KVEventsConfig, KVTransferConfig
 from vllm.distributed.kv_events import BlockStored, KVEventBatch
+from vllm.utils.system_utils import set_env_var
 
-CPU_BLOCK_SIZES = [16, 48]
+CPU_BLOCK_SIZES = [48]
+ATTN_BACKENDS = ["FLASH_ATTN", "FLASHINFER"]
 
 
 class MockSubscriber:
@@ -63,8 +65,88 @@ class MockSubscriber:
         self.sub.close()
 
 
+def _latency_test(llm: LLM, subscriber: MockSubscriber):
+    sampling_params = SamplingParams(max_tokens=1)
+
+    num_times_cpu_better_than_cold = 0
+    num_tests = 10
+    total_cold_time = 0.0
+    total_gpu_hit_time = 0.0
+    total_cpu_hit_time = 0.0
+    prompt_token_ids = [0] * 10001
+    for i in tqdm(range(num_tests), desc="Running tests"):
+        prompt_token_ids[0] = i
+        prompts = [TokensPrompt(prompt_token_ids=prompt_token_ids)]
+
+        # run generation - this should trigger saving KV cache
+        start_time = time.time()
+        llm.generate(prompts, sampling_params, use_tqdm=False)
+        cold_time = time.time() - start_time
+        total_cold_time += cold_time
+
+        # run generation again - should hit the GPU prefix cache
+        start_time = time.time()
+        llm.generate(prompts, sampling_params, use_tqdm=False)
+        gpu_hit_time = time.time() - start_time
+        total_gpu_hit_time += gpu_hit_time
+
+        # reset prefix cache to avoid GPU hit.
+        llm.reset_prefix_cache()
+
+        assert subscriber.get_new_cpu_stored_events()
+
+        # run generation again - this should trigger loading from CPU
+        start_time = time.time()
+        llm.generate(prompts, sampling_params, use_tqdm=False)
+        cpu_hit_time = time.time() - start_time
+        total_cpu_hit_time += cpu_hit_time
+
+        if cpu_hit_time < cold_time:
+            num_times_cpu_better_than_cold += 1
+
+    print("Average times:")
+    print(f"    Cold: {total_cold_time * 1000 / num_tests:.2f}ms")
+    print(f"    GPU hit: {total_gpu_hit_time * 1000 / num_tests:.2f}ms")
+    print(f"    CPU hit: {total_cpu_hit_time * 1000 / num_tests:.2f}ms")
+
+    assert num_times_cpu_better_than_cold >= 0.8 * num_tests
+
+
+def _accuracy_test(llm: LLM, subscriber: MockSubscriber):
+    sampling_params = SamplingParams(max_tokens=1)
+    cpu_block_size = (
+        llm.llm_engine.vllm_config.kv_transfer_config.kv_connector_extra_config[
+            "block_size"
+        ]
+    )
+
+    subscriber.get_new_cpu_stored_events()
+
+    # prepend prompt to be cpu block aligned
+    prompt = "Let's count to 10. One, two, three, four,"
+    while (
+        len(llm.generate(prompt, use_tqdm=False)[0].prompt_token_ids) % cpu_block_size
+        != 0
+    ):
+        prompt = ". " + prompt
+
+    assert subscriber.get_new_cpu_stored_events()
+
+    test_count = 100
+    success_count = 0
+    for i in range(test_count):
+        if (
+            llm.generate(prompt, sampling_params, use_tqdm=False)[0].outputs[0].text
+            == " five"
+        ):
+            success_count += 1
+
+    assert success_count >= 0.5 * test_count
+
+
 @pytest.mark.parametrize("cpu_block_size", CPU_BLOCK_SIZES)
-def test_cpu_offloading(cpu_block_size: int) -> None:
+@pytest.mark.parametrize("attn_backend", ATTN_BACKENDS)
+def test_cpu_offloading(cpu_block_size: int, attn_backend: str) -> None:
     """
     Tests OffloadingConnector with CPUOffloadingSpec.
     """
@@ -92,61 +174,20 @@ def test_cpu_offloading(cpu_block_size: int) -> None:
         topic="test",
     )
 
-    llm = LLM(
-        model="meta-llama/Llama-3.2-1B-Instruct",
-        gpu_memory_utilization=0.5,
-        kv_events_config=kv_events_config,
-        kv_transfer_config=kv_transfer_config,
-    )
-
-    sampling_params = SamplingParams(temperature=0, max_tokens=1)
+    with set_env_var("VLLM_ATTENTION_BACKEND", attn_backend):
+        llm = LLM(
+            model="meta-llama/Llama-3.2-1B-Instruct",
+            gpu_memory_utilization=0.5,
+            kv_events_config=kv_events_config,
+            kv_transfer_config=kv_transfer_config,
+        )
 
     events_endpoint = events_endpoint.replace("*", "127.0.0.1")
     subscriber = MockSubscriber(events_endpoint, topic=kv_events_config.topic)
 
     try:
-        num_times_cpu_better_than_cold = 0
-        num_tests = 10
-        total_cold_time = 0.0
-        total_gpu_hit_time = 0.0
-        total_cpu_hit_time = 0.0
-        prompt_token_ids = [0] * 10001
-        for i in tqdm(range(num_tests), desc="Running tests"):
-            prompt_token_ids[0] = i
-            prompts = [TokensPrompt(prompt_token_ids=prompt_token_ids)]
-
-            # run generation - this should trigger saving KV cache
-            start_time = time.time()
-            llm.generate(prompts, sampling_params, use_tqdm=False)
-            cold_time = time.time() - start_time
-            total_cold_time += cold_time
-
-            # run generation again - should hit the GPU prefix cache
-            start_time = time.time()
-            llm.generate(prompts, sampling_params, use_tqdm=False)
-            gpu_hit_time = time.time() - start_time
-            total_gpu_hit_time += gpu_hit_time
-
-            # reset prefix cache to avoid GPU hit.
-            llm.reset_prefix_cache()
-
-            assert subscriber.get_new_cpu_stored_events()
-
-            # run generation again - this should trigger loading from CPU
-            start_time = time.time()
-            llm.generate(prompts, sampling_params, use_tqdm=False)
-            cpu_hit_time = time.time() - start_time
-            total_cpu_hit_time += cpu_hit_time
-
-            if cpu_hit_time < cold_time:
-                num_times_cpu_better_than_cold += 1
-
-        print("Average times:")
-        print(f"    Cold: {total_cold_time * 1000 / num_tests:.2f}ms")
-        print(f"    GPU hit: {total_gpu_hit_time * 1000 / num_tests:.2f}ms")
-        print(f"    CPU hit: {total_cpu_hit_time * 1000 / num_tests:.2f}ms")
-
-        assert num_times_cpu_better_than_cold >= 0.8 * num_tests
+        _latency_test(llm, subscriber)
+        _accuracy_test(llm, subscriber)
     finally:
         subscriber.close()
         del llm
diff --git a/tests/v1/worker/test_gpu_model_runner.py b/tests/v1/worker/test_gpu_model_runner.py
index 824e458978350..01c1364f7ee62 100644
--- a/tests/v1/worker/test_gpu_model_runner.py
+++ b/tests/v1/worker/test_gpu_model_runner.py
@@ -483,7 +483,10 @@ def test_kv_cache_stride_order(monkeypatch, model_runner):
     # Permutation that gets you back to expected kv shape
     for test_stride in ((1, 4, 0, 2, 3), (0, 1, 2, 3, 4)):
 
-        def rnd_stride_order(test_stride=test_stride):
+        def rnd_stride_order(
+            include_num_layers_dimension: bool = False, test_stride=test_stride
+        ):
+            assert not include_num_layers_dimension
             return test_stride
 
         # Patch the attention backend class and re-trigger the KV cache creation
diff --git a/vllm/attention/backends/abstract.py b/vllm/attention/backends/abstract.py
index 188becb6ad6f0..67ded88475243 100644
--- a/vllm/attention/backends/abstract.py
+++ b/vllm/attention/backends/abstract.py
@@ -76,7 +76,34 @@ class AttentionBackend(ABC):
         raise NotImplementedError
 
     @staticmethod
-    def get_kv_cache_stride_order() -> tuple[int, ...]:
+    def get_kv_cache_stride_order(
+        include_num_layers_dimension: bool = False,
+    ) -> tuple[int, ...]:
+        """
+        Get the physical (memory layout) ordering of the kv cache dimensions.
+        e.g. if the KV cache shape is
+        [2, num_blocks, block_size, num_heads, head_size],
+        and get_kv_cache_stride_order returns (1, 3, 0, 2, 4) then the physical
+        ordering of dimensions is
+        [num_blocks, num_heads, 2, block_size, head_size].
+
+        If this function is unimplemented / raises NotImplementedError,
+        the physical layout of the KV cache will match the logical shape.
+
+        Args:
+            include_num_layers_dimension: if True, includes an additional
+                num_layers dimension, which is assumed to be prepended
+                to the logical KV cache shape.
+                With the above example, a return value (2, 4, 0, 1, 3, 5)
+                corresponds to
+                [num_blocks, num_heads, num_layers, 2, block_size, head_size].
+
+                If an additional dimension is NOT included in the returned
+                tuple, the physical layout will not include a layers dimension.
+
+        Returns:
+            A tuple of ints which is a permutation of range(len(shape)).
+        """
         raise NotImplementedError
 
     @classmethod
diff --git a/vllm/distributed/kv_transfer/kv_connector/v1/base.py b/vllm/distributed/kv_transfer/kv_connector/v1/base.py
index f85eb414b2222..74f09278b7bb1 100644
--- a/vllm/distributed/kv_transfer/kv_connector/v1/base.py
+++ b/vllm/distributed/kv_transfer/kv_connector/v1/base.py
@@ -38,7 +38,7 @@ The class provides the following primitives:
 import enum
 from abc import ABC, abstractmethod
 from collections.abc import Callable, Iterable
-from typing import TYPE_CHECKING, Any, Literal, Optional
+from typing import TYPE_CHECKING, Any, ClassVar, Literal, Optional
 
 import torch
 
@@ -47,7 +47,7 @@ from vllm.v1.core.sched.output import SchedulerOutput
 from vllm.v1.outputs import KVConnectorOutput
 
 if TYPE_CHECKING:
-    from vllm.attention.backends.abstract import AttentionMetadata
+    from vllm.attention.backends.abstract import AttentionBackend, AttentionMetadata
     from vllm.config import VllmConfig
     from vllm.distributed.kv_events import KVCacheEvent
     from vllm.distributed.kv_transfer.kv_connector.v1.metrics import (
@@ -142,6 +142,18 @@ class KVConnectorMetadata(ABC):  # noqa: B024
 
 
 class KVConnectorBase_V1(ABC):
+    """
+    Base class for KV connectors.
+
+    Attributes:
+        prefer_cross_layer_blocks (bool): Indicates whether this connector
+            prefers KV blocks that hold KV data for all layers (for speeding
+            up KV data transfers).
+            Defaults to False.
+    """
+
+    prefer_cross_layer_blocks: ClassVar[bool] = False
+
     def __init__(
         self,
         vllm_config: "VllmConfig",
@@ -226,6 +238,23 @@ class KVConnectorBase_V1(ABC):
         """
         return
 
+    def register_cross_layers_kv_cache(
+        self, kv_cache: torch.Tensor, attn_backend: type["AttentionBackend"]
+    ):
+        """
+        Initialize with a single KV cache tensor used by all layers.
+        The first dimension should be num_layers.
+        This function will only be called for models with uniform layers,
+        and only if the prefers_cross_layer_blocks is set to True.
+        Only one of the functions
+        {register_kv_caches, register_cross_layers_kv_cache} will be called.
+
+        Args:
+            kv_cache: a cross-layers kv cache tensor
+            attn_backend: The attention backend that corresponds to all layers
+        """
+        return
+
     def set_host_xfer_buffer_ops(self, copy_operation: CopyBlocksOp):
         """
         Set the xPU-specific ops for copying KV between host and device.
diff --git a/vllm/distributed/kv_transfer/kv_connector/v1/offloading_connector.py b/vllm/distributed/kv_transfer/kv_connector/v1/offloading_connector.py
index 582e42cc466ae..8cd09014cab11 100644
--- a/vllm/distributed/kv_transfer/kv_connector/v1/offloading_connector.py
+++ b/vllm/distributed/kv_transfer/kv_connector/v1/offloading_connector.py
@@ -4,12 +4,12 @@ from collections import defaultdict
 from collections.abc import Iterable, Iterator
 from dataclasses import dataclass
 from itertools import islice
-from typing import Any
+from typing import Any, ClassVar
 
 import torch
 
-from vllm.attention import AttentionMetadata
-from vllm.config import VllmConfig
+from vllm.attention import Attention, AttentionBackend, AttentionMetadata
+from vllm.config import VllmConfig, get_layers_from_vllm_config
 from vllm.distributed.kv_events import BlockRemoved, BlockStored, KVCacheEvent
 from vllm.distributed.kv_transfer.kv_connector.v1 import (
     KVConnectorBase_V1,
@@ -42,6 +42,8 @@ class OffloadingConnectorMetadata(KVConnectorMetadata):
 
 
 class OffloadingConnector(KVConnectorBase_V1):
+    prefer_cross_layer_blocks: ClassVar[bool] = True
+
     def __init__(
         self,
         vllm_config: VllmConfig,
@@ -63,6 +65,12 @@ class OffloadingConnector(KVConnectorBase_V1):
         assert self.connector_worker is not None
         self.connector_worker.register_kv_caches(kv_caches)
 
+    def register_cross_layers_kv_cache(
+        self, kv_cache: torch.Tensor, attn_backend: type[AttentionBackend]
+    ):
+        assert self.connector_worker is not None
+        self.connector_worker.register_cross_layers_kv_cache(kv_cache, attn_backend)
+
     def start_load_kv(self, forward_context: "ForwardContext", **kwargs) -> None:
         assert self.connector_worker is not None
         assert isinstance(self._connector_metadata, OffloadingConnectorMetadata)
@@ -422,10 +430,35 @@ class OffloadingConnectorWorker:
         self._job_counter = job_id + 1
         return job_id
 
-    def register_kv_caches(self, kv_caches: dict[str, torch.Tensor]):
-        for src_cls, dst_cls, handler in self.spec.get_handlers(kv_caches):
+    def _register_handlers(
+        self,
+        kv_caches: dict[str, torch.Tensor],
+        attn_backends: dict[str, type[AttentionBackend]],
+    ):
+        for src_cls, dst_cls, handler in self.spec.get_handlers(
+            kv_caches, attn_backends
+        ):
             self.worker.register_handler(src_cls, dst_cls, handler)
 
+    def register_kv_caches(self, kv_caches: dict[str, torch.Tensor]):
+        layer_names = list(kv_caches.keys())
+        layers = get_layers_from_vllm_config(
+            self.spec.vllm_config, Attention, layer_names
+        )
+        attn_backends = {
+            layer_name: layers[layer_name].get_attn_backend()
+            for layer_name in layer_names
+        }
+        self._register_handlers(kv_caches, attn_backends)
+
+    def register_cross_layers_kv_cache(
+        self, kv_cache: torch.Tensor, attn_backend: type[AttentionBackend]
+    ):
+        cross_layer_name = "ALL_LAYERS"
+        kv_caches = {cross_layer_name: kv_cache}
+        attn_backends = {cross_layer_name: attn_backend}
+        self._register_handlers(kv_caches, attn_backends)
+
     def start_load_kv(self, metadata: OffloadingConnectorMetadata):
         for req_id, transfer_spec in metadata.reqs_to_load.items():
             job_id = self._generate_job_id()
diff --git a/vllm/v1/attention/backends/flash_attn.py b/vllm/v1/attention/backends/flash_attn.py
index cf3c1d05f5b3f..9fa6b1dfd19dd 100755
--- a/vllm/v1/attention/backends/flash_attn.py
+++ b/vllm/v1/attention/backends/flash_attn.py
@@ -99,12 +99,20 @@ class FlashAttentionBackend(AttentionBackend):
         return (2, num_blocks, block_size, num_kv_heads, head_size)
 
     @staticmethod
-    def get_kv_cache_stride_order() -> tuple[int, ...]:
+    def get_kv_cache_stride_order(
+        include_num_layers_dimension: bool = False,
+    ) -> tuple[int, ...]:
         # `stride_order` indicates the permutation that gets
         # us from `get_kv_cache_shape` to the actual memory layout we want.
         cache_layout = get_kv_cache_layout()
-        if cache_layout == "NHD":
+        if cache_layout == "NHD" and include_num_layers_dimension:
+            # (num_blocks, num_layers, 2, block_size, num_kv_heads, head_size)
+            return (2, 0, 1, 3, 4, 5)
+        elif cache_layout == "NHD":
             stride_order = (0, 1, 2, 3, 4)
+        elif cache_layout == "HND" and include_num_layers_dimension:
+            # (num_blocks, num_kv_heads, num_layers, 2, block_size, head_size)
+            return (2, 4, 0, 1, 3, 5)
         elif cache_layout == "HND":
             stride_order = (0, 1, 3, 2, 4)
         else:
diff --git a/vllm/v1/attention/backends/flashinfer.py b/vllm/v1/attention/backends/flashinfer.py
index 4da1637d96eb6..3ad7e8c52fc1f 100755
--- a/vllm/v1/attention/backends/flashinfer.py
+++ b/vllm/v1/attention/backends/flashinfer.py
@@ -309,12 +309,20 @@ class FlashInferBackend(AttentionBackend):
         return (num_blocks, 2, block_size, num_kv_heads, head_size)
 
     @staticmethod
-    def get_kv_cache_stride_order() -> tuple[int, ...]:
+    def get_kv_cache_stride_order(
+        include_num_layers_dimension: bool = False,
+    ) -> tuple[int, ...]:
         # `stride_order` indicates the permutation that gets us from
         # `get_kv_cache_shape` to the actual memory layout we want.
         cache_layout = get_kv_cache_layout()
-        if cache_layout == "NHD":
+        if cache_layout == "NHD" and include_num_layers_dimension:
+            # (num_blocks, num_layers, 2, block_size, num_kv_heads, head_size)
+            return (1, 0, 2, 3, 4, 5)
+        elif cache_layout == "NHD":
             stride_order = (0, 1, 2, 3, 4)
+        elif cache_layout == "HND" and include_num_layers_dimension:
+            # (num_blocks, 2, num_kv_heads, num_layers, block_size, head_size)
+            return (1, 2, 4, 0, 3, 5)
         elif cache_layout == "HND":
             stride_order = (0, 1, 3, 2, 4)
         else:
diff --git a/vllm/v1/attention/backends/mla/common.py b/vllm/v1/attention/backends/mla/common.py
index 32f406980f2ed..43aef8a7cca91 100755
--- a/vllm/v1/attention/backends/mla/common.py
+++ b/vllm/v1/attention/backends/mla/common.py
@@ -308,6 +308,15 @@ class MLACommonBackend(AttentionBackend):
     ) -> tuple[int, ...]:
         return (num_blocks, block_size, head_size)
 
+    @staticmethod
+    def get_kv_cache_stride_order(
+        include_num_layers_dimension: bool = False,
+    ) -> tuple[int, ...]:
+        # `stride_order` indicates the permutation that gets
+        # us from `get_kv_cache_shape` to the actual memory layout we want.
+        # (num_blocks, num_layers, block_size, head_size)
+        return (1, 0, 2, 3) if include_num_layers_dimension else (0, 1, 2)
+
     @classmethod
     def get_supported_head_sizes(cls) -> list[int]:
         return [576]
diff --git a/vllm/v1/attention/backends/mla/indexer.py b/vllm/v1/attention/backends/mla/indexer.py
index cc0988435768c..d38361e0fcbf8 100644
--- a/vllm/v1/attention/backends/mla/indexer.py
+++ b/vllm/v1/attention/backends/mla/indexer.py
@@ -48,7 +48,11 @@ class DeepseekV32IndexerBackend(AttentionBackend):
         return (num_blocks, block_size, head_size)
 
     @staticmethod
-    def get_kv_cache_stride_order() -> tuple[int, ...]:
+    def get_kv_cache_stride_order(
+        include_num_layers_dimension: bool = False,
+    ) -> tuple[int, ...]:
+        if include_num_layers_dimension:
+            return (0, 1, 2, 3)
         return (0, 1, 2)
 
 
diff --git a/vllm/v1/kv_offload/cpu.py b/vllm/v1/kv_offload/cpu.py
index 4b1bbe6f0cc2a..86747299eb107 100644
--- a/vllm/v1/kv_offload/cpu.py
+++ b/vllm/v1/kv_offload/cpu.py
@@ -4,8 +4,8 @@ from collections.abc import Iterator
 
 import torch
 
-from vllm.config import VllmConfig, get_layers_from_vllm_config
-from vllm.model_executor.layers.attention_layer_base import AttentionLayerBase
+from vllm.attention import AttentionBackend
+from vllm.config import VllmConfig
 from vllm.platforms import current_platform
 from vllm.v1.kv_offload.abstract import LoadStoreSpec, OffloadingManager
 from vllm.v1.kv_offload.arc_manager import ARCOffloadingManager
@@ -63,7 +63,9 @@ class CPUOffloadingSpec(OffloadingSpec):
         return self._manager
 
     def get_handlers(
-        self, kv_caches: dict[str, torch.Tensor]
+        self,
+        kv_caches: dict[str, torch.Tensor],
+        attn_backends: dict[str, type[AttentionBackend]],
     ) -> Iterator[tuple[type[LoadStoreSpec], type[LoadStoreSpec], OffloadingHandler]]:
         if not self._handler:
             if not current_platform.is_cuda_alike():
@@ -71,15 +73,6 @@ class CPUOffloadingSpec(OffloadingSpec):
                     "CPU Offloading is currently only supported on CUDA-alike GPUs"
                 )
 
-            layer_names = list(kv_caches.keys())
-            layers = get_layers_from_vllm_config(
-                self.vllm_config, AttentionLayerBase, layer_names
-            )
-            attn_backends = {
-                layer_name: layers[layer_name].get_attn_backend()
-                for layer_name in layer_names
-            }
-
             self._handler = CpuGpuOffloadingHandler(
                 attn_backends=attn_backends,
                 gpu_block_size=self.gpu_block_size,
diff --git a/vllm/v1/kv_offload/spec.py b/vllm/v1/kv_offload/spec.py
index a3c539a47d458..c1813a4ff4ea9 100644
--- a/vllm/v1/kv_offload/spec.py
+++ b/vllm/v1/kv_offload/spec.py
@@ -11,6 +11,7 @@ from vllm.v1.kv_offload.abstract import LoadStoreSpec, OffloadingManager
 from vllm.v1.kv_offload.worker.worker import OffloadingHandler
 
 if TYPE_CHECKING:
+    from vllm.attention import AttentionBackend
     from vllm.config import VllmConfig
 
 logger = init_logger(__name__)
@@ -48,13 +49,16 @@ class OffloadingSpec(ABC):
 
     @abstractmethod
     def get_handlers(
-        self, kv_caches: dict[str, torch.Tensor]
+        self,
+        kv_caches: dict[str, torch.Tensor],
+        attn_backends: dict[str, type["AttentionBackend"]],
     ) -> Iterator[tuple[type[LoadStoreSpec], type[LoadStoreSpec], OffloadingHandler]]:
         """
         Get offloading handlers along with their respective src and dst types.
 
         Args:
             kv_caches: A dictionary of layer_name -> gpu_kv_cache tensor.
+            attn_backends: A dictionary of layer_name -> AttentionBackend.
 
         Yields:
             Tuples of (src_type, dst_type, offloading_handler).
diff --git a/vllm/v1/kv_offload/worker/cpu_gpu.py b/vllm/v1/kv_offload/worker/cpu_gpu.py
index 111046377a5da..bb163f0043fc6 100644
--- a/vllm/v1/kv_offload/worker/cpu_gpu.py
+++ b/vllm/v1/kv_offload/worker/cpu_gpu.py
@@ -83,10 +83,18 @@ class CpuGpuOffloadingHandler(OffloadingHandler):
             self.gpu_tensors.append(gpu_tensor)
 
             gpu_shape = gpu_tensor.shape
-            test_shape = attn_backends[layer_name].get_kv_cache_shape(
+            attn_backend = attn_backends[layer_name]
+            test_shape = attn_backend.get_kv_cache_shape(
                 num_blocks=1234, block_size=16, num_kv_heads=8, head_size=256
             )
-            if test_shape[0] == 1234:
+
+            if len(gpu_shape) != len(test_shape):
+                # cross-layers tensor
+                # shape is (num_blocks, ...)
+                assert len(gpu_shape) == len(test_shape) + 1
+                num_blocks_idx = 0
+                self.kv_dim_before_num_blocks.append(False)
+            elif test_shape[0] == 1234:
                 # shape is (num_blocks, ...)
                 num_blocks_idx = 0
                 self.kv_dim_before_num_blocks.append(False)
diff --git a/vllm/v1/worker/gpu_model_runner.py b/vllm/v1/worker/gpu_model_runner.py
index 0490ed39c8c78..4b0a08ab57e16 100644
--- a/vllm/v1/worker/gpu_model_runner.py
+++ b/vllm/v1/worker/gpu_model_runner.py
@@ -349,6 +349,9 @@ class GPUModelRunner(
         # self.model: nn.Module  # Set after load_model
         # Initialize in initialize_kv_cache
         self.kv_caches: list[torch.Tensor] = []
+        # Initialize in initialize_kv_cache_tensors
+        self.cross_layers_kv_cache: torch.Tensor | None = None
+        self.cross_layers_attn_backend: type[AttentionBackend] | None = None
         # indexes: [kv_cache_group_id][attn_group]
         self.attn_groups: list[list[AttentionGroup]] = []
         # self.kv_cache_config: KVCacheConfig
@@ -4930,12 +4933,30 @@ class GPUModelRunner(
             Dict[str, torch.Tensor]: A map between layer names to their
             corresponding memory buffer for KV cache.
         """
-        # Initialize the memory buffer for KV cache
-        kv_cache_raw_tensors = self._allocate_kv_cache_tensors(kv_cache_config)
-        # Change the memory buffer to the desired shape
-        kv_caches = self._reshape_kv_cache_tensors(
-            kv_cache_config, kv_cache_raw_tensors, kernel_block_sizes
-        )
+
+        # Try creating KV caches optimized for kv-connector transfers
+        cache_dtype = self.cache_config.cache_dtype
+        if self.use_uniform_kv_cache(self.attn_groups, cache_dtype):
+            kv_caches, cross_layers_kv_cache, attn_backend = (
+                self.allocate_uniform_kv_caches(
+                    kv_cache_config,
+                    self.attn_groups,
+                    cache_dtype,
+                    self.device,
+                    kernel_block_sizes,
+                )
+            )
+            self.cross_layers_kv_cache = cross_layers_kv_cache
+            self.cross_layers_attn_backend = attn_backend
+        else:
+            # Fallback to the general case
+            # Initialize the memory buffer for KV cache
+            kv_cache_raw_tensors = self._allocate_kv_cache_tensors(kv_cache_config)
+
+            # Change the memory buffer to the desired shape
+            kv_caches = self._reshape_kv_cache_tensors(
+                kv_cache_config, kv_cache_raw_tensors, kernel_block_sizes
+            )
 
         # Set up cross-layer KV cache sharing
         for layer_name, target_layer_name in self.shared_kv_cache_layers.items():
@@ -5017,7 +5038,13 @@ class GPUModelRunner(
 
         if has_kv_transfer_group():
             kv_transfer_group = get_kv_transfer_group()
-            kv_transfer_group.register_kv_caches(kv_caches)
+            if self.cross_layers_kv_cache is not None:
+                assert self.cross_layers_attn_backend is not None
+                kv_transfer_group.register_cross_layers_kv_cache(
+                    self.cross_layers_kv_cache, self.cross_layers_attn_backend
+                )
+            else:
+                kv_transfer_group.register_kv_caches(kv_caches)
             kv_transfer_group.set_host_xfer_buffer_ops(copy_kv_blocks)
 
         if self.dcp_world_size > 1:
diff --git a/vllm/v1/worker/kv_connector_model_runner_mixin.py b/vllm/v1/worker/kv_connector_model_runner_mixin.py
index db037a9fccd5c..e59361f21372a 100644
--- a/vllm/v1/worker/kv_connector_model_runner_mixin.py
+++ b/vllm/v1/worker/kv_connector_model_runner_mixin.py
@@ -11,7 +11,11 @@ from typing import (
     TYPE_CHECKING,  # noqa: UP035
 )
 
+import torch
+
+from vllm.attention import AttentionBackend
 from vllm.config import VllmConfig
+from vllm.config.cache import CacheDType
 from vllm.distributed.kv_transfer import (
     ensure_kv_transfer_shutdown,
     get_kv_transfer_group,
@@ -21,11 +25,13 @@ from vllm.distributed.kv_transfer.kv_connector.base import KVConnectorBase
 from vllm.distributed.kv_transfer.kv_connector.v1.metrics import KVConnectorStats
 from vllm.forward_context import get_forward_context, set_forward_context
 from vllm.logger import init_logger
+from vllm.v1.kv_cache_interface import AttentionSpec, KVCacheConfig
 from vllm.v1.outputs import (
     EMPTY_MODEL_RUNNER_OUTPUT,
     KVConnectorOutput,
     ModelRunnerOutput,
 )
+from vllm.v1.worker.utils import AttentionGroup
 
 if TYPE_CHECKING:
     from vllm.v1.core.sched.output import SchedulerOutput
@@ -142,3 +148,162 @@ class KVConnectorModelRunnerMixin:
         if has_kv_transfer_group():
             return get_kv_transfer_group().get_kv_connector_stats()
         return None
+
+    @staticmethod
+    def use_uniform_kv_cache(
+        attn_groups: list[list[AttentionGroup]],
+        cache_dtype: CacheDType,
+    ) -> bool:
+        """
+        Determines whether a uniform KV layout should be used.
+        A uniform layout means all layers KV caches will share the same
+        underlying tensor, where for a given block number, the respective
+        KV data for all layers will be contiguous.
+        This will allow efficient KV transfer of per-block KV data for all
+        layers at once.
+        Note this layout will only be applied given 3 conditions:
+        1. The KV Cache config contains just a single group where all layers
+            have the same page size.
+        2. A KV connector is configured, and the KV connector instance prefers
+            to use this layout (prefer_cross_layer_blocks() returns True)
+        2. The flash attention backend supports this layout
+            (get_kv_cache_stride_order(True) includes a placement for a
+            num_layers dimension)
+
+        Note that the actual placement of the num_layers dimensions
+        in the unified layers tensors will be determined by the attention
+        backend.
+        Thus, the layers KV data may still not be contiguous per block
+        if the attention backend does not support it.
+
+        Args:
+            attn_groups: The list of attention groups for this model
+            cache_dtype: The KV cache dtype
+        Returns:
+            True if we should use a uniform KV cache layout.
+        """
+
+        if not has_kv_transfer_group():
+            return False
+        if not get_kv_transfer_group().prefer_cross_layer_blocks:
+            return False
+
+        if len(attn_groups) != 1 or len(attn_groups[0]) != 1:
+            return False
+
+        attn_group = attn_groups[0][0]
+        kv_cache_spec = attn_group.kv_cache_spec
+        if not isinstance(kv_cache_spec, AttentionSpec):
+            return False
+
+        attn_backend = attn_group.backend
+        kv_cache_shape = attn_backend.get_kv_cache_shape(
+            1234,
+            kv_cache_spec.block_size,
+            kv_cache_spec.num_kv_heads,
+            kv_cache_spec.head_size,
+            cache_dtype_str=cache_dtype,
+        )
+
+        try:
+            kv_cache_stride_order = attn_backend.get_kv_cache_stride_order(
+                include_num_layers_dimension=True
+            )
+        except (AttributeError, NotImplementedError):
+            return False
+
+        # check that attention backend include a layers dimension
+        return len(kv_cache_stride_order) == len(kv_cache_shape) + 1
+
+    @staticmethod
+    def allocate_uniform_kv_caches(
+        kv_cache_config: KVCacheConfig,
+        attn_groups: list[list[AttentionGroup]],
+        cache_dtype: CacheDType,
+        device: torch.device,
+        kernel_block_sizes: list[int],
+    ) -> tuple[dict[str, torch.Tensor], torch.Tensor, type[AttentionBackend]]:
+        """
+        Initializes and reshapes KV caches for the simple case where all
+        layers have the same layout.
+
+        This function assumes use_uniform_kv_cache() returned True.
+
+        Args:
+            kv_cache_config: The KV cache config
+            attn_groups: The list of attention groups for this model
+            cache_dtype: The KV cache dtype
+            device: The torch device to allocate on.
+            kernel_block_sizes: The kernel block sizes for each KV cache group.
+        Returns:
+            A tuple (kv_caches, cross_layers_kv_cache, attn_backend) where:
+                kv_caches is a dict mapping between layer names to their
+                    corresponding memory buffer for KV cache.
+                cross_layers_kv_cache is the cross layers kv cache tensor
+                attn_backend is the attention backend matching this tensor
+        """
+        attn_group = attn_groups[0][0]
+        kv_cache_spec = attn_group.kv_cache_spec
+        assert isinstance(kv_cache_spec, AttentionSpec)
+
+        tensor_sizes = set(
+            kv_cache_tensor.size for kv_cache_tensor in kv_cache_config.kv_cache_tensors
+        )
+        assert len(tensor_sizes) == 1
+        tensor_size = tensor_sizes.pop()
+
+        page_size = kv_cache_spec.page_size_bytes
+        assert tensor_size % page_size == 0
+        num_blocks = tensor_size // page_size
+        num_layers = len(kv_cache_config.kv_cache_tensors)
+        total_size = tensor_size * num_layers
+
+        assert len(kernel_block_sizes) == 1
+        kernel_block_size = kernel_block_sizes[0]
+        num_blocks_per_kv_block = kv_cache_spec.block_size // kernel_block_size
+        kernel_num_blocks = num_blocks * num_blocks_per_kv_block
+
+        attn_backend = attn_group.backend
+        kv_cache_shape = attn_backend.get_kv_cache_shape(
+            kernel_num_blocks,
+            kernel_block_size,
+            kv_cache_spec.num_kv_heads,
+            kv_cache_spec.head_size,
+            cache_dtype_str=cache_dtype,
+        )
+
+        # prepend a num_layers dimension into the shape
+        kv_cache_shape = (num_layers,) + kv_cache_shape
+
+        try:
+            kv_cache_stride_order = attn_backend.get_kv_cache_stride_order(
+                include_num_layers_dimension=True
+            )
+            assert len(kv_cache_stride_order) == len(kv_cache_shape)
+        except (AttributeError, NotImplementedError):
+            kv_cache_stride_order = tuple(range(len(kv_cache_shape)))
+
+        kv_cache_shape = tuple(kv_cache_shape[i] for i in kv_cache_stride_order)
+
+        logger.info("Allocating a cross layer KV cache of shape %s", kv_cache_shape)
+
+        # allocate one contiguous buffer for all layers
+        cross_layers_kv_cache = (
+            torch.zeros(total_size, dtype=torch.int8, device=device)
+            .view(kv_cache_spec.dtype)
+            .view(kv_cache_shape)
+        )
+
+        # Maintain original KV shape view.
+        inv_order = [
+            kv_cache_stride_order.index(i) for i in range(len(kv_cache_stride_order))
+        ]
+        permuted_kv_cache = cross_layers_kv_cache.permute(*inv_order)
+
+        kv_caches = {}
+        for i, kv_cache_tensor in enumerate(kv_cache_config.kv_cache_tensors):
+            tensor = permuted_kv_cache[i]
+            for layer_name in kv_cache_tensor.shared_by:
+                kv_caches[layer_name] = tensor
+
+        return kv_caches, cross_layers_kv_cache, attn_backend