diff --git a/tests/config/test_config_generation.py b/tests/config/test_config_generation.py
new file mode 100644
index 000000000000..024e81fccc5f
--- /dev/null
+++ b/tests/config/test_config_generation.py
@@ -0,0 +1,38 @@
+# SPDX-License-Identifier: Apache-2.0
+# SPDX-FileCopyrightText: Copyright contributors to the vLLM project
+import pytest
+
+from vllm.engine.arg_utils import EngineArgs
+from vllm.model_executor.layers.quantization.quark.utils import deep_compare
+
+
+def test_cuda_empty_vs_unset_configs(monkeypatch: pytest.MonkeyPatch):
+    """Test that configs created with normal (untouched) CUDA_VISIBLE_DEVICES
+    and CUDA_VISIBLE_DEVICES="" are equivalent. This ensures consistent
+    behavior regardless of whether GPU visibility is disabled via empty string
+    or left in its normal state.
+    """
+
+    def create_config():
+        engine_args = EngineArgs(model="deepseek-ai/DeepSeek-V2-Lite",
+                                 trust_remote_code=True)
+        return engine_args.create_engine_config()
+
+    # Create config with CUDA_VISIBLE_DEVICES set normally
+    normal_config = create_config()
+
+    # Create config with CUDA_VISIBLE_DEVICES=""
+    with monkeypatch.context() as m:
+        m.setenv("CUDA_VISIBLE_DEVICES", "")
+        empty_config = create_config()
+
+    normal_config_dict = vars(normal_config)
+    empty_config_dict = vars(empty_config)
+
+    # Remove instance_id before comparison as it's expected to be different
+    normal_config_dict.pop("instance_id", None)
+    empty_config_dict.pop("instance_id", None)
+
+    assert deep_compare(normal_config_dict, empty_config_dict), (
+        "Configs with normal CUDA_VISIBLE_DEVICES and CUDA_VISIBLE_DEVICES=\"\""
+        " should be equivalent")
diff --git a/tests/v1/engine/test_engine_core_client.py b/tests/v1/engine/test_engine_core_client.py
index 16c36cd5c6b9..d5ff78c1449a 100644
--- a/tests/v1/engine/test_engine_core_client.py
+++ b/tests/v1/engine/test_engine_core_client.py
@@ -8,8 +8,10 @@ import time
 import uuid
 from threading import Thread
 from typing import Optional
+from unittest.mock import MagicMock
 
 import pytest
+import torch
 from transformers import AutoTokenizer
 
 from tests.utils import multi_gpu_test
@@ -517,3 +519,72 @@ def test_startup_failure(monkeypatch: pytest.MonkeyPatch):
         )
 
     assert "Engine core initialization failed" in str(e_info.value)
+
+
+@create_new_process_for_each_test()
+def test_engine_core_proc_instantiation_cuda_empty(
+        monkeypatch: pytest.MonkeyPatch):
+    """
+    Test that EngineCoreProc can be instantiated when CUDA_VISIBLE_DEVICES
+    is empty. This ensures the engine frontend does not need access to GPUs.
+    """
+
+    from vllm.v1.engine.core import EngineCoreProc
+    from vllm.v1.executor.abstract import Executor
+
+    # Create a simple mock executor instead of a complex custom class
+    mock_executor_class = MagicMock(spec=Executor)
+
+    def create_mock_executor(vllm_config):
+        mock_executor = MagicMock()
+
+        # Only implement the methods that are actually called during init
+        from vllm.v1.kv_cache_interface import FullAttentionSpec
+        mock_spec = FullAttentionSpec(block_size=16,
+                                      num_kv_heads=1,
+                                      head_size=64,
+                                      dtype=torch.float16,
+                                      use_mla=False)
+
+        mock_executor.get_kv_cache_specs.return_value = [{
+            "default": mock_spec
+        }]
+        mock_executor.determine_available_memory.return_value = [
+            1024 * 1024 * 1024
+        ]
+        mock_executor.initialize_from_config.return_value = None
+        mock_executor.max_concurrent_batches = 1
+
+        return mock_executor
+
+    mock_executor_class.side_effect = create_mock_executor
+
+    with monkeypatch.context() as m:
+        m.setenv("VLLM_USE_V1", "1")
+        m.setenv("CUDA_VISIBLE_DEVICES", "")  # No CUDA devices
+
+        from vllm.v1.utils import EngineZmqAddresses
+
+        def mock_startup_handshake(self, handshake_socket, on_head_node,
+                                   parallel_config):
+            return EngineZmqAddresses(inputs=["tcp://127.0.0.1:5555"],
+                                      outputs=["tcp://127.0.0.1:5556"],
+                                      coordinator_input=None,
+                                      coordinator_output=None)
+
+        # Background processes are not important here
+        m.setattr(EngineCoreProc, "startup_handshake", mock_startup_handshake)
+
+        vllm_config = EngineArgs(
+            model="deepseek-ai/DeepSeek-V2-Lite",
+            trust_remote_code=True).create_engine_config()
+        engine_core_proc = EngineCoreProc(
+            vllm_config=vllm_config,
+            on_head_node=True,
+            handshake_address="tcp://127.0.0.1:12345",
+            executor_class=mock_executor_class,
+            log_stats=False,
+            engine_index=0,
+        )
+
+        engine_core_proc.shutdown()
diff --git a/vllm/platforms/interface.py b/vllm/platforms/interface.py
index f962fafabf50..0f08bf986333 100644
--- a/vllm/platforms/interface.py
+++ b/vllm/platforms/interface.py
@@ -173,17 +173,12 @@ class Platform:
 
     @classmethod
     def device_id_to_physical_device_id(cls, device_id: int):
-        if cls.device_control_env_var in os.environ:
+        # Treat empty device control env var as unset. This is a valid
+        # configuration in Ray setups where the engine is launched in
+        # a CPU-only placement group located on a GPU node.
+        if cls.device_control_env_var in os.environ and os.environ[
+                cls.device_control_env_var] != "":
             device_ids = os.environ[cls.device_control_env_var].split(",")
-            if device_ids == [""]:
-                msg = (f"{cls.device_control_env_var} is set to empty string, "
-                       "which means current platform support is disabled. If "
-                       "you are using ray, please unset the environment "
-                       f"variable `{cls.device_control_env_var}` inside the "
-                       "worker/actor. Check "
-                       "https://github.com/vllm-project/vllm/issues/8402 for "
-                       "more information.")
-                raise RuntimeError(msg)
             physical_device_id = device_ids[device_id]
             return int(physical_device_id)
         else: