diff --git a/.buildkite/release-pipeline.yaml b/.buildkite/release-pipeline.yaml
index 597dfbf99022..a1de41652c9a 100644
--- a/.buildkite/release-pipeline.yaml
+++ b/.buildkite/release-pipeline.yaml
@@ -149,3 +149,25 @@ steps:
       - "docker push public.ecr.aws/q9t5s3a7/vllm-cpu-release-repo:$(buildkite-agent meta-data get release-version)"
     env:
       DOCKER_BUILDKIT: "1"
+
+  - label: "Build and publish nightly multi-arch image to DockerHub"
+    depends_on:
+      - create-multi-arch-manifest
+    if: build.env("NIGHTLY") == "1"
+    agents:
+      queue: cpu_queue_postmerge
+    commands:
+      - "aws ecr-public get-login-password --region us-east-1 | docker login --username AWS --password-stdin public.ecr.aws/q9t5s3a7"
+      - "docker pull public.ecr.aws/q9t5s3a7/vllm-release-repo:$BUILDKITE_COMMIT"
+      - "docker tag public.ecr.aws/q9t5s3a7/vllm-release-repo:$BUILDKITE_COMMIT vllm/vllm-openai:nightly"
+      - "docker tag public.ecr.aws/q9t5s3a7/vllm-release-repo:$BUILDKITE_COMMIT vllm/vllm-openai:nightly-$BUILDKITE_COMMIT"
+      - "docker push vllm/vllm-openai:nightly"
+      - "docker push vllm/vllm-openai:nightly-$BUILDKITE_COMMIT"
+      # Clean up old nightly builds (keep only last 14)
+      - "bash .buildkite/scripts/cleanup-nightly-builds.sh"
+    plugins:
+      - docker-login#v3.0.0:
+          username: vllmbot
+          password-env: DOCKERHUB_TOKEN
+    env:
+      DOCKER_BUILDKIT: "1"
diff --git a/.buildkite/scripts/cleanup-nightly-builds.sh b/.buildkite/scripts/cleanup-nightly-builds.sh
new file mode 100755
index 000000000000..1a82f7d08523
--- /dev/null
+++ b/.buildkite/scripts/cleanup-nightly-builds.sh
@@ -0,0 +1,97 @@
+#!/bin/bash
+
+set -ex
+
+# Clean up old nightly builds from DockerHub, keeping only the last 14 builds
+# This script uses DockerHub API to list and delete old tags with "nightly-" prefix
+
+# DockerHub API endpoint for vllm/vllm-openai repository
+REPO_API_URL="https://hub.docker.com/v2/repositories/vllm/vllm-openai/tags"
+
+# Get DockerHub token from environment
+if [ -z "$DOCKERHUB_TOKEN" ]; then
+    echo "Error: DOCKERHUB_TOKEN environment variable is not set"
+    exit 1
+fi
+
+# Function to get all tags from DockerHub
+get_all_tags() {
+    local page=1
+    local all_tags=""
+    
+    while true; do
+        local response=$(curl -s -H "Authorization: Bearer $DOCKERHUB_TOKEN" \
+            "$REPO_API_URL?page=$page&page_size=100")
+        
+        # Get both last_updated timestamp and tag name, separated by |
+        local tags=$(echo "$response" | jq -r '.results[] | select(.name | startswith("nightly-")) | "\(.last_updated)|\(.name)"')
+        
+        if [ -z "$tags" ]; then
+            break
+        fi
+        
+        all_tags="$all_tags$tags"$'\n'
+        page=$((page + 1))
+    done
+    
+    # Sort by timestamp (newest first) and extract just the tag names
+    echo "$all_tags" | sort -r | cut -d'|' -f2
+}
+
+delete_tag() {
+    local tag_name="$1"
+    echo "Deleting tag: $tag_name"
+    
+    local delete_url="https://hub.docker.com/v2/repositories/vllm/vllm-openai/tags/$tag_name"
+    local response=$(curl -s -X DELETE -H "Authorization: Bearer $DOCKERHUB_TOKEN" "$delete_url")
+    
+    if echo "$response" | jq -e '.detail' > /dev/null 2>&1; then
+        echo "Warning: Failed to delete tag $tag_name: $(echo "$response" | jq -r '.detail')"
+    else
+        echo "Successfully deleted tag: $tag_name"
+    fi
+}
+
+# Get all nightly- prefixed tags, sorted by last_updated timestamp (newest first)
+echo "Fetching all tags from DockerHub..."
+all_tags=$(get_all_tags)
+
+if [ -z "$all_tags" ]; then
+    echo "No tags found to clean up"
+    exit 0
+fi
+
+# Count total tags
+total_tags=$(echo "$all_tags" | wc -l)
+echo "Found $total_tags tags"
+
+# Keep only the last 14 builds (including the current one)
+tags_to_keep=14
+tags_to_delete=$((total_tags - tags_to_keep))
+
+if [ $tags_to_delete -le 0 ]; then
+    echo "No tags need to be deleted (only $total_tags tags found, keeping $tags_to_keep)"
+    exit 0
+fi
+
+echo "Will delete $tags_to_delete old tags, keeping the newest $tags_to_keep"
+
+# Get tags to delete (skip the first $tags_to_keep tags)
+tags_to_delete_list=$(echo "$all_tags" | tail -n +$((tags_to_keep + 1)))
+
+if [ -z "$tags_to_delete_list" ]; then
+    echo "No tags to delete"
+    exit 0
+fi
+
+# Delete old tags
+echo "Deleting old tags..."
+while IFS= read -r tag; do
+    if [ -n "$tag" ]; then
+        delete_tag "$tag"
+        # Add a small delay to avoid rate limiting
+        sleep 1
+    fi
+done <<< "$tags_to_delete_list"
+
+echo "Cleanup completed successfully"