diff --git a/vllm/model_executor/models/qwen2_5_omni_thinker.py b/vllm/model_executor/models/qwen2_5_omni_thinker.py
index d05eb76cdf6f..e79428d17a70 100644
--- a/vllm/model_executor/models/qwen2_5_omni_thinker.py
+++ b/vllm/model_executor/models/qwen2_5_omni_thinker.py
@@ -41,6 +41,7 @@ from transformers.models.whisper import WhisperFeatureExtractor
 from vllm.config import VllmConfig
 from vllm.logger import init_logger
 from vllm.model_executor.layers.rotary_embedding import MRotaryEmbedding
+from vllm.model_executor.models.module_mapping import MultiModelKeys
 from vllm.model_executor.models.qwen2_5_vl import (
     Qwen2_5_VisionTransformer, Qwen2_5_VLImageEmbeddingInputs,
     Qwen2_5_VLImageInputs, Qwen2_5_VLImagePixelInputs,
@@ -66,7 +67,8 @@ from vllm.sequence import IntermediateTensors
 from vllm.transformers_utils.tokenizer import decode_tokens, encode_tokens
 from vllm.utils.tensor_schema import TensorSchema, TensorShape
 
-from .interfaces import MultiModalEmbeddings, SupportsMultiModal, SupportsPP
+from .interfaces import (MultiModalEmbeddings, SupportsLoRA,
+                         SupportsMultiModal, SupportsPP)
 from .utils import (AutoWeightsLoader, WeightsMapper,
                     init_vllm_registered_model, maybe_prefix,
                     merge_multimodal_embeddings)
@@ -726,7 +728,7 @@ class Qwen2_5OmniConditionalGenerationMixin:
     dummy_inputs=Qwen2_5OmniThinkerDummyInputsBuilder,
 )
 class Qwen2_5OmniThinkerForConditionalGeneration(
-        nn.Module, SupportsMultiModal, SupportsPP,
+        nn.Module, SupportsMultiModal, SupportsPP, SupportsLoRA,
         Qwen2_5OmniConditionalGenerationMixin):
     hf_to_vllm_mapper = WeightsMapper(
         orig_to_new_prefix={
@@ -734,6 +736,22 @@ class Qwen2_5OmniThinkerForConditionalGeneration(
             "thinker.model.": "language_model.model.",
             "thinker.": "",
         })
+    packed_modules_mapping = {
+        "qkv_proj": [
+            "q_proj",
+            "k_proj",
+            "v_proj",
+        ],
+        "attn.qkv": [
+            "attn.q",
+            "attn.k",
+            "attn.v",
+        ],
+        "gate_up_proj": [
+            "gate_proj",
+            "up_proj",
+        ],
+    }
 
     @classmethod
     def get_placeholder_str(cls, modality: str, i: int) -> Optional[str]:
@@ -956,3 +974,12 @@ class Qwen2_5OmniThinkerForConditionalGeneration(
                                              mapper=self.hf_to_vllm_mapper)
 
         return loaded_weights
+
+    def get_mm_mapping(self) -> MultiModelKeys:
+        """
+        Get the module prefix in multimodal models
+        """
+        return MultiModelKeys.from_string_field(
+            language_model="language_model",
+            connector="merger.",
+            tower_model=["visual.", "audio_tower."])