diff --git a/.buildkite/scripts/run-prime-rl-test.sh b/.buildkite/scripts/run-prime-rl-test.sh
new file mode 100755
index 0000000000000..5b25c358fc4aa
--- /dev/null
+++ b/.buildkite/scripts/run-prime-rl-test.sh
@@ -0,0 +1,59 @@
+#!/bin/bash
+# SPDX-License-Identifier: Apache-2.0
+# SPDX-FileCopyrightText: Copyright contributors to the vLLM project
+
+# Setup script for Prime-RL integration tests
+# This script prepares the environment for running Prime-RL tests with nightly vLLM
+
+set -euo pipefail
+
+SCRIPT_DIR="$(cd "$(dirname "${BASH_SOURCE[0]}")" && pwd)"
+REPO_ROOT="$(cd "${SCRIPT_DIR}/../.." && pwd)"
+PRIME_RL_REPO="https://github.com/PrimeIntellect-ai/prime-rl.git"
+PRIME_RL_DIR="${REPO_ROOT}/prime-rl"
+
+echo "Setting up Prime-RL integration test environment..."
+
+# Clean up any existing Prime-RL directory
+if [ -d "${PRIME_RL_DIR}" ]; then
+    echo "Removing existing Prime-RL directory..."
+    rm -rf "${PRIME_RL_DIR}"
+fi
+
+# Install UV if not available
+if ! command -v uv &> /dev/null; then
+    echo "Installing UV package manager..."
+    curl -LsSf https://astral.sh/uv/install.sh | sh
+    source $HOME/.local/bin/env
+fi
+
+# Clone Prime-RL repository at specific branch for reproducible tests
+PRIME_RL_BRANCH="integ-vllm-main"
+echo "Cloning Prime-RL repository at branch: ${PRIME_RL_BRANCH}..."
+git clone --branch "${PRIME_RL_BRANCH}" --single-branch "${PRIME_RL_REPO}" "${PRIME_RL_DIR}"
+cd "${PRIME_RL_DIR}"
+
+echo "Setting up UV project environment..."
+export UV_PROJECT_ENVIRONMENT=/usr/local
+ln -s /usr/bin/python3 /usr/local/bin/python
+
+# Remove vllm pin from pyproject.toml
+echo "Removing vllm pin from pyproject.toml..."
+sed -i '/vllm==/d' pyproject.toml
+
+# Sync Prime-RL dependencies
+echo "Installing Prime-RL dependencies..."
+uv sync --inexact && uv sync --inexact --all-extras
+
+# Verify installation
+echo "Verifying installations..."
+uv run python -c "import vllm; print(f'vLLM version: {vllm.__version__}')"
+uv run python -c "import prime_rl; print('Prime-RL imported successfully')"
+
+echo "Prime-RL integration test environment setup complete!"
+
+echo "Running Prime-RL integration tests..."
+export WANDB_MODE=offline # this makes this test not require a WANDB_API_KEY
+uv run pytest -vs tests/integration/test_rl.py -m gpu
+
+echo "Prime-RL integration tests completed!"
diff --git a/.buildkite/test-pipeline.yaml b/.buildkite/test-pipeline.yaml
index 245d21b778c05..200ed344c4e86 100644
--- a/.buildkite/test-pipeline.yaml
+++ b/.buildkite/test-pipeline.yaml
@@ -1045,3 +1045,15 @@ steps:
   commands:
     - pytest -v -s tests/distributed/test_context_parallel.py
     - pytest -v -s tests/distributed/test_nccl_symm_mem_allreduce.py
+
+##### RL Integration Tests #####
+- label: Prime-RL Integration Test # 15min
+  timeout_in_minutes: 30
+  optional: true
+  num_gpus: 2
+  working_dir: "/vllm-workspace"
+  source_file_dependencies:
+  - vllm/
+  - .buildkite/scripts/run-prime-rl-test.sh
+  commands:
+    - bash .buildkite/scripts/run-prime-rl-test.sh