diff --git a/docs/cli/README.md b/docs/cli/README.md
index b1371c82a4c4..a7de6d7192ac 100644
--- a/docs/cli/README.md
+++ b/docs/cli/README.md
@@ -29,6 +29,9 @@ Start the vLLM OpenAI Compatible API server.
     # Specify the port
     vllm serve meta-llama/Llama-2-7b-hf --port 8100
 
+    # Serve over a Unix domain socket
+    vllm serve meta-llama/Llama-2-7b-hf --uds /tmp/vllm.sock
+
     # Check with --help for more options
     # To list all groups
     vllm serve --help=listgroup
diff --git a/tests/entrypoints/openai/test_uds.py b/tests/entrypoints/openai/test_uds.py
new file mode 100644
index 000000000000..5c39869a794f
--- /dev/null
+++ b/tests/entrypoints/openai/test_uds.py
@@ -0,0 +1,43 @@
+# SPDX-License-Identifier: Apache-2.0
+# SPDX-FileCopyrightText: Copyright contributors to the vLLM project
+
+from tempfile import TemporaryDirectory
+
+import httpx
+import pytest
+
+from vllm.version import __version__ as VLLM_VERSION
+
+from ...utils import RemoteOpenAIServer
+
+MODEL_NAME = "HuggingFaceH4/zephyr-7b-beta"
+
+
+@pytest.fixture(scope="module")
+def server():
+    with TemporaryDirectory() as tmpdir:
+        args = [
+            # use half precision for speed and memory savings in CI environment
+            "--dtype",
+            "bfloat16",
+            "--max-model-len",
+            "8192",
+            "--enforce-eager",
+            "--max-num-seqs",
+            "128",
+            "--uds",
+            f"{tmpdir}/vllm.sock",
+        ]
+
+        with RemoteOpenAIServer(MODEL_NAME, args) as remote_server:
+            yield remote_server
+
+
+@pytest.mark.asyncio
+async def test_show_version(server: RemoteOpenAIServer):
+    transport = httpx.HTTPTransport(uds=server.uds)
+    client = httpx.Client(transport=transport)
+    response = client.get(server.url_for("version"))
+    response.raise_for_status()
+
+    assert response.json() == {"version": VLLM_VERSION}
diff --git a/tests/utils.py b/tests/utils.py
index 741b4401cc21..18fcde949160 100644
--- a/tests/utils.py
+++ b/tests/utils.py
@@ -17,6 +17,7 @@ from pathlib import Path
 from typing import Any, Callable, Literal, Optional, Union
 
 import cloudpickle
+import httpx
 import openai
 import pytest
 import requests
@@ -88,10 +89,12 @@ class RemoteOpenAIServer:
                 raise ValueError("You have manually specified the port "
                                  "when `auto_port=True`.")
 
-            # Don't mutate the input args
-            vllm_serve_args = vllm_serve_args + [
-                "--port", str(get_open_port())
-            ]
+            # No need for a port if using unix sockets
+            if "--uds" not in vllm_serve_args:
+                # Don't mutate the input args
+                vllm_serve_args = vllm_serve_args + [
+                    "--port", str(get_open_port())
+                ]
         if seed is not None:
             if "--seed" in vllm_serve_args:
                 raise ValueError("You have manually specified the seed "
@@ -104,8 +107,13 @@ class RemoteOpenAIServer:
         subparsers = parser.add_subparsers(required=False, dest="subparser")
         parser = ServeSubcommand().subparser_init(subparsers)
         args = parser.parse_args(["--model", model, *vllm_serve_args])
-        self.host = str(args.host or 'localhost')
-        self.port = int(args.port)
+        self.uds = args.uds
+        if args.uds:
+            self.host = None
+            self.port = None
+        else:
+            self.host = str(args.host or 'localhost')
+            self.port = int(args.port)
 
         self.show_hidden_metrics = \
             args.show_hidden_metrics_for_version is not None
@@ -150,9 +158,11 @@ class RemoteOpenAIServer:
     def _wait_for_server(self, *, url: str, timeout: float):
         # run health check
         start = time.time()
+        client = (httpx.Client(transport=httpx.HTTPTransport(
+            uds=self.uds)) if self.uds else requests)
         while True:
             try:
-                if requests.get(url).status_code == 200:
+                if client.get(url).status_code == 200:
                     break
             except Exception:
                 # this exception can only be raised by requests.get,
@@ -170,7 +180,8 @@ class RemoteOpenAIServer:
 
     @property
     def url_root(self) -> str:
-        return f"http://{self.host}:{self.port}"
+        return (f"http://{self.uds.split('/')[-1]}"
+                if self.uds else f"http://{self.host}:{self.port}")
 
     def url_for(self, *parts: str) -> str:
         return self.url_root + "/" + "/".join(parts)
diff --git a/vllm/entrypoints/openai/api_server.py b/vllm/entrypoints/openai/api_server.py
index 00eaba8c872f..e5d31c1fd03f 100644
--- a/vllm/entrypoints/openai/api_server.py
+++ b/vllm/entrypoints/openai/api_server.py
@@ -1777,6 +1777,12 @@ def create_server_socket(addr: tuple[str, int]) -> socket.socket:
     return sock
 
 
+def create_server_unix_socket(path: str) -> socket.socket:
+    sock = socket.socket(family=socket.AF_UNIX, type=socket.SOCK_STREAM)
+    sock.bind(path)
+    return sock
+
+
 def validate_api_server_args(args):
     valid_tool_parses = ToolParserManager.tool_parsers.keys()
     if args.enable_auto_tool_choice \
@@ -1807,8 +1813,11 @@ def setup_server(args):
     # workaround to make sure that we bind the port before the engine is set up.
     # This avoids race conditions with ray.
     # see https://github.com/vllm-project/vllm/issues/8204
-    sock_addr = (args.host or "", args.port)
-    sock = create_server_socket(sock_addr)
+    if args.uds:
+        sock = create_server_unix_socket(args.uds)
+    else:
+        sock_addr = (args.host or "", args.port)
+        sock = create_server_socket(sock_addr)
 
     # workaround to avoid footguns where uvicorn drops requests with too
     # many concurrent requests active
@@ -1820,12 +1829,14 @@ def setup_server(args):
 
     signal.signal(signal.SIGTERM, signal_handler)
 
-    addr, port = sock_addr
-    is_ssl = args.ssl_keyfile and args.ssl_certfile
-    host_part = f"[{addr}]" if is_valid_ipv6_address(
-        addr) else addr or "0.0.0.0"
-    listen_address = f"http{'s' if is_ssl else ''}://{host_part}:{port}"
-
+    if args.uds:
+        listen_address = f"unix:{args.uds}"
+    else:
+        addr, port = sock_addr
+        is_ssl = args.ssl_keyfile and args.ssl_certfile
+        host_part = f"[{addr}]" if is_valid_ipv6_address(
+            addr) else addr or "0.0.0.0"
+        listen_address = f"http{'s' if is_ssl else ''}://{host_part}:{port}"
     return listen_address, sock
 
 
diff --git a/vllm/entrypoints/openai/cli_args.py b/vllm/entrypoints/openai/cli_args.py
index e89463a03cda..e15f65b43082 100644
--- a/vllm/entrypoints/openai/cli_args.py
+++ b/vllm/entrypoints/openai/cli_args.py
@@ -72,6 +72,8 @@ class FrontendArgs:
     """Host name."""
     port: int = 8000
     """Port number."""
+    uds: Optional[str] = None
+    """Unix domain socket path. If set, host and port arguments are ignored."""
     uvicorn_log_level: Literal["debug", "info", "warning", "error", "critical",
                                "trace"] = "info"
     """Log level for uvicorn."""