diff --git a/tests/compile/test_full_graph.py b/tests/compile/test_full_graph.py
index 870aa553ca628..f9f146810924e 100644
--- a/tests/compile/test_full_graph.py
+++ b/tests/compile/test_full_graph.py
@@ -139,6 +139,21 @@ def test_custom_compile_config(
     run_model(compilation_config, model, model_kwargs)
 
 
+@pytest.mark.parametrize(
+    "optimization_level",
+    [CompilationLevel.NO_COMPILATION, CompilationLevel.PIECEWISE],
+)
+def test_fp8_kv_scale_compile(optimization_level: int):
+    model = "Qwen/Qwen2-0.5B"
+    model_kwargs = {
+        "quantization": "fp8",
+        "kv_cache_dtype": "fp8_e4m3",
+        "calculate_kv_scales": True,
+        "max_model_len": 512,
+    }
+    run_model(optimization_level, model, model_kwargs)
+
+
 def test_inductor_graph_partition_attn_fusion(caplog_vllm):
     if not is_torch_equal_or_newer("2.9.0.dev"):
         pytest.skip("inductor graph partition is only available "
diff --git a/vllm/attention/layer.py b/vllm/attention/layer.py
index 326fe6dd048a9..d97c87d96e999 100644
--- a/vllm/attention/layer.py
+++ b/vllm/attention/layer.py
@@ -277,9 +277,8 @@ class Attention(nn.Module, AttentionLayerBase):
         `vllm.forward_context.get_forward_context().attn_metadata`.
         """
         if self.calculate_kv_scales:
-            attn_metadata = get_forward_context().attn_metadata
-            if attn_metadata.enable_kv_scales_calculation:
-                self.calc_kv_scales(query, key, value)
+            torch.ops.vllm.maybe_calc_kv_scales(query, key, value,
+                                                self.layer_name)
 
         output_dtype = query.dtype
         if self.query_quant is not None:
@@ -554,6 +553,44 @@ def maybe_save_kv_layer_to_connector(
                             attn_metadata[layer_name])
 
 
+def maybe_calc_kv_scales(
+    query: torch.Tensor,
+    key: torch.Tensor,
+    value: torch.Tensor,
+    layer_name: str,
+) -> None:
+
+    forward_context: ForwardContext = get_forward_context()
+    attn_metadata = forward_context.attn_metadata
+
+    if isinstance(attn_metadata, dict):
+        attn_metadata = attn_metadata[layer_name]
+
+    if attn_metadata is None or not getattr(
+            attn_metadata, 'enable_kv_scales_calculation', False):
+        return
+
+    self = forward_context.no_compile_layers[layer_name]
+    self.calc_kv_scales(query, key, value)
+
+
+def maybe_calc_kv_scales_fake(
+    query: torch.Tensor,
+    key: torch.Tensor,
+    value: torch.Tensor,
+    layer_name: str,
+) -> None:
+    return
+
+
+direct_register_custom_op(
+    op_name="maybe_calc_kv_scales",
+    op_func=maybe_calc_kv_scales,
+    mutates_args=["query", "key", "value"],
+    fake_impl=maybe_calc_kv_scales_fake,
+)
+
+
 def unified_attention(
     query: torch.Tensor,
     key: torch.Tensor,
diff --git a/vllm/v1/worker/gpu_model_runner.py b/vllm/v1/worker/gpu_model_runner.py
index f8b0b9cba1bc1..9e7d6eb0387bc 100644
--- a/vllm/v1/worker/gpu_model_runner.py
+++ b/vllm/v1/worker/gpu_model_runner.py
@@ -2351,6 +2351,15 @@ class GPUModelRunner(LoRAModelRunnerMixin, KVConnectorModelRunnerMixin):
                 self.cudagraph_dispatcher.dispatch(batch_descriptor,
                                                    use_cascade_attn)
 
+        # Set cudagraph mode to none if calc_kv_scales is true.
+        if attn_metadata is not None:
+            metadata_list = (attn_metadata.values() if isinstance(
+                attn_metadata, dict) else [attn_metadata])
+            if any(
+                    getattr(m, 'enable_kv_scales_calculation', False)
+                    for m in metadata_list):
+                cudagraph_runtime_mode = CUDAGraphMode.NONE
+
         # This is currently to get around the assert in the DPMetadata
         # where it wants `num_tokens_across_dp` to align with `num_tokens`
         if ubatch_slices is not None: