diff --git a/vllm/model_executor/layers/fused_moe/configs/E=62,N=128,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=62,N=128,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 0000000000000..40d86ff8ba324
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=62,N=128,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,200 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "64": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "96": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "128": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "256": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "512": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 32,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 32,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 32,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=62,N=256,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=62,N=256,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 0000000000000..6014d827d7417
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=62,N=256,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,200 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "64": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "96": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "128": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "256": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "512": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 16,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=62,N=512,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=62,N=512,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 0000000000000..3622659f3e915
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=62,N=512,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,200 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "8": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "16": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 16,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "64": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 16,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "96": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "128": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "256": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "512": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 16,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 16,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=72,N=192,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=72,N=192,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 0000000000000..311d2e829a050
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=72,N=192,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,200 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
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+        "kpack": 2
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+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=72,N=384,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=72,N=384,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 0000000000000..91c4b916b8649
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=72,N=384,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,200 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 1,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "24": {
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+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "32": {
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+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
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+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
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+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
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+        "GROUP_SIZE_M": 8,
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+        "num_stages": 2,
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+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
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+    },
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+        "waves_per_eu": 0,
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+        "kpack": 2
+    },
+    "2048": {
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+        "BLOCK_SIZE_N": 256,
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+    },
+    "3072": {
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+    },
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+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
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+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=72,N=768,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=72,N=768,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 0000000000000..8fee30ec70660
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=72,N=768,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,200 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "8": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "16": {
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+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
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+        "kpack": 2
+    },
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+        "GROUP_SIZE_M": 1,
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+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "32": {
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+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
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+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "128": {
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+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
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+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
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+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
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+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
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+        "kpack": 2
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+        "num_stages": 2,
+        "waves_per_eu": 0,
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+        "kpack": 2
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+    },
+    "3072": {
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+    }
+}