diff --git a/CMakeLists.txt b/CMakeLists.txt
index ba3991372fabe..cbac8b8397fa3 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -86,6 +86,9 @@ find_package(Torch REQUIRED)
 # Supported NVIDIA architectures.
 # This check must happen after find_package(Torch) because that's when CMAKE_CUDA_COMPILER_VERSION gets defined
 if(DEFINED CMAKE_CUDA_COMPILER_VERSION AND
+   CMAKE_CUDA_COMPILER_VERSION VERSION_GREATER_EQUAL 13.0)
+  set(CUDA_SUPPORTED_ARCHS "7.5;8.0;8.6;8.7;8.9;9.0;10.0;11.0;12.0")
+elseif(DEFINED CMAKE_CUDA_COMPILER_VERSION AND
    CMAKE_CUDA_COMPILER_VERSION VERSION_GREATER_EQUAL 12.8)
   set(CUDA_SUPPORTED_ARCHS "7.0;7.2;7.5;8.0;8.6;8.7;8.9;9.0;10.0;10.1;12.0")
 else()
@@ -175,6 +178,15 @@ if(NVCC_THREADS AND VLLM_GPU_LANG STREQUAL "CUDA")
   list(APPEND VLLM_GPU_FLAGS "--threads=${NVCC_THREADS}")
 endif()
 
+#
+# Set compression mode for CUDA >=13.x.
+#
+if(VLLM_GPU_LANG STREQUAL "CUDA" AND
+   DEFINED CMAKE_CUDA_COMPILER_VERSION AND
+   CMAKE_CUDA_COMPILER_VERSION VERSION_GREATER_EQUAL 13.0)
+  list(APPEND VLLM_GPU_FLAGS "--compress-mode=size")
+endif()
+
 #
 # Set CUDA include flags for CXX compiler.
 #
@@ -270,7 +282,7 @@ if(VLLM_GPU_LANG STREQUAL "CUDA")
   SET(CUTLASS_ENABLE_HEADERS_ONLY ON CACHE BOOL "Enable only the header library")
 
   # Set CUTLASS_REVISION. Used for FetchContent. Also fixes some bogus messages when building.
-  set(CUTLASS_REVISION "v4.0.0" CACHE STRING "CUTLASS revision to use")
+  set(CUTLASS_REVISION "v4.2.1" CACHE STRING "CUTLASS revision to use")
 
   # Use the specified CUTLASS source directory for compilation if VLLM_CUTLASS_SRC_DIR is provided
   if (DEFINED ENV{VLLM_CUTLASS_SRC_DIR})
@@ -305,7 +317,6 @@ if(VLLM_GPU_LANG STREQUAL "CUDA")
     "csrc/quantization/w8a8/cutlass/scaled_mm_entry.cu"
     "csrc/quantization/fp4/nvfp4_quant_entry.cu"
     "csrc/quantization/fp4/nvfp4_scaled_mm_entry.cu"
-    "csrc/quantization/fp4/nvfp4_blockwise_moe_kernel.cu"
     "csrc/sparse/cutlass/sparse_scaled_mm_entry.cu"
     "csrc/cutlass_extensions/common.cpp"
     "csrc/quantization/w8a8/fp8/per_token_group_quant.cu"
@@ -441,7 +452,11 @@ if(VLLM_GPU_LANG STREQUAL "CUDA")
 
   # The cutlass_scaled_mm kernels for Geforce Blackwell SM120 (c3x, i.e. CUTLASS 3.x) require
   # CUDA 12.8 or later
-  cuda_archs_loose_intersection(SCALED_MM_ARCHS "12.0;12.0a" "${CUDA_ARCHS}")
+  if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 13.0)
+    cuda_archs_loose_intersection(SCALED_MM_ARCHS "12.0f" "${CUDA_ARCHS}")
+  else()
+    cuda_archs_loose_intersection(SCALED_MM_ARCHS "12.0a" "${CUDA_ARCHS}")
+  endif()
   if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 12.8 AND SCALED_MM_ARCHS)
     set(SRCS
       "csrc/quantization/w8a8/cutlass/scaled_mm_c3x_sm120.cu"
@@ -471,7 +486,11 @@ if(VLLM_GPU_LANG STREQUAL "CUDA")
 
   # The cutlass_scaled_mm kernels for Blackwell SM100 (c3x, i.e. CUTLASS 3.x)
   # require CUDA 12.8 or later
-  cuda_archs_loose_intersection(SCALED_MM_ARCHS "10.0a;10.1a" "${CUDA_ARCHS}")
+  if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 13.0)
+    cuda_archs_loose_intersection(SCALED_MM_ARCHS "10.0f;11.0f;12.0f" "${CUDA_ARCHS}")
+  else()
+    cuda_archs_loose_intersection(SCALED_MM_ARCHS "10.0a;10.1a;10.3a;12.0a;12.1a" "${CUDA_ARCHS}")
+  endif()
   if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 12.8 AND SCALED_MM_ARCHS)
     set(SRCS
       "csrc/quantization/w8a8/cutlass/scaled_mm_c3x_sm100.cu"
@@ -551,7 +570,11 @@ if(VLLM_GPU_LANG STREQUAL "CUDA")
 
   # The nvfp4_scaled_mm_sm120 kernels for Geforce Blackwell SM120 require
   # CUDA 12.8 or later
-  cuda_archs_loose_intersection(FP4_ARCHS "12.0;12.0a" "${CUDA_ARCHS}")
+  if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 13.0)
+    cuda_archs_loose_intersection(FP4_ARCHS "12.0f" "${CUDA_ARCHS}")
+  else()
+    cuda_archs_loose_intersection(FP4_ARCHS "12.0a" "${CUDA_ARCHS}")
+  endif()
   if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 12.8 AND FP4_ARCHS)
     set(SRCS
       "csrc/quantization/fp4/nvfp4_quant_kernels.cu"
@@ -570,7 +593,11 @@ if(VLLM_GPU_LANG STREQUAL "CUDA")
   endif()
 
   # FP4 Archs and flags
-  cuda_archs_loose_intersection(FP4_ARCHS "10.0a" "${CUDA_ARCHS}")
+  if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 13.0)
+    cuda_archs_loose_intersection(FP4_ARCHS "10.0f;11.0f;12.0f" "${CUDA_ARCHS}")
+  else()
+    cuda_archs_loose_intersection(FP4_ARCHS "10.0a;10.1a;12.0a;12.1a" "${CUDA_ARCHS}")
+  endif()
   if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 12.8 AND FP4_ARCHS)
     set(SRCS
       "csrc/quantization/fp4/nvfp4_quant_kernels.cu"
@@ -592,7 +619,11 @@ if(VLLM_GPU_LANG STREQUAL "CUDA")
   endif()
 
   # CUTLASS MLA Archs and flags
-  cuda_archs_loose_intersection(MLA_ARCHS "10.0a" "${CUDA_ARCHS}")
+  if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 13.0)
+    cuda_archs_loose_intersection(MLA_ARCHS "10.0f;11.0f;12.0f" "${CUDA_ARCHS}")
+  else()
+    cuda_archs_loose_intersection(MLA_ARCHS "10.0a;10.1a;10.3a;12.0a;12.1a" "${CUDA_ARCHS}")
+  endif()
   if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 12.8 AND MLA_ARCHS)
     set(SRCS
       "csrc/attention/mla/sm100_cutlass_mla_kernel.cu")
@@ -636,7 +667,11 @@ if(VLLM_GPU_LANG STREQUAL "CUDA")
     endif()
   endif()
 
-  cuda_archs_loose_intersection(SCALED_MM_ARCHS "10.0a" "${CUDA_ARCHS}")
+  if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 13.0)
+    cuda_archs_loose_intersection(SCALED_MM_ARCHS "10.0f" "${CUDA_ARCHS}")
+  else()
+    cuda_archs_loose_intersection(SCALED_MM_ARCHS "10.0a" "${CUDA_ARCHS}")
+  endif()
   if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 12.8 AND SCALED_MM_ARCHS)
     set(SRCS "csrc/quantization/w8a8/cutlass/moe/grouped_mm_c3x_sm100.cu")
     set_gencode_flags_for_srcs(
@@ -657,7 +692,11 @@ if(VLLM_GPU_LANG STREQUAL "CUDA")
   endif()
 
   # moe_data.cu is used by all CUTLASS MoE kernels.
-  cuda_archs_loose_intersection(CUTLASS_MOE_DATA_ARCHS "9.0a;10.0a" "${CUDA_ARCHS}")
+  if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 13.0)
+    cuda_archs_loose_intersection(CUTLASS_MOE_DATA_ARCHS "9.0a;10.0f;11.0f;12.0f" "${CUDA_ARCHS}")
+  else()
+    cuda_archs_loose_intersection(CUTLASS_MOE_DATA_ARCHS "9.0a;10.0a;10.1a;10.3a;12.0a;12.1a" "${CUDA_ARCHS}")
+  endif()
   if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 12.3 AND CUTLASS_MOE_DATA_ARCHS)
     set(SRCS "csrc/quantization/w8a8/cutlass/moe/moe_data.cu")
     set_gencode_flags_for_srcs(
@@ -676,7 +715,11 @@ if(VLLM_GPU_LANG STREQUAL "CUDA")
     endif()
   endif()
 
-  cuda_archs_loose_intersection(SCALED_MM_ARCHS "10.0a" "${CUDA_ARCHS}")
+  if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 13.0)
+    cuda_archs_loose_intersection(SCALED_MM_ARCHS "10.0f;11.0f;12.0f" "${CUDA_ARCHS}")
+  else()
+    cuda_archs_loose_intersection(SCALED_MM_ARCHS "10.0a;10.1a;10.3a;12.0a;12.1a" "${CUDA_ARCHS}")
+  endif()
   if(${CMAKE_CUDA_COMPILER_VERSION} VERSION_GREATER_EQUAL 12.8 AND SCALED_MM_ARCHS)
     set(SRCS "csrc/quantization/w8a8/cutlass/moe/blockwise_scaled_group_mm_sm100.cu")
     set_gencode_flags_for_srcs(
diff --git a/cmake/utils.cmake b/cmake/utils.cmake
index 8558976e2c392..f6a0d2b75be1a 100644
--- a/cmake/utils.cmake
+++ b/cmake/utils.cmake
@@ -310,13 +310,13 @@ function(cuda_archs_loose_intersection OUT_CUDA_ARCHS SRC_CUDA_ARCHS TGT_CUDA_AR
   list(REMOVE_DUPLICATES _PTX_ARCHS)
   list(REMOVE_DUPLICATES _SRC_CUDA_ARCHS)
 
-  # if x.0a is in SRC_CUDA_ARCHS and x.0 is in CUDA_ARCHS then we should
-  # remove x.0a from SRC_CUDA_ARCHS and add x.0a to _CUDA_ARCHS
+  # If x.0a or x.0f is in SRC_CUDA_ARCHS and x.0 is in CUDA_ARCHS then we should
+  # remove x.0a or x.0f from SRC_CUDA_ARCHS and add x.0a or x.0f to _CUDA_ARCHS
   set(_CUDA_ARCHS)
   foreach(_arch ${_SRC_CUDA_ARCHS})
-    if(_arch MATCHES "\\a$")
+    if(_arch MATCHES "[af]$")
       list(REMOVE_ITEM _SRC_CUDA_ARCHS "${_arch}")
-      string(REPLACE "a" "" _base "${_arch}")
+      string(REGEX REPLACE "[af]$" "" _base "${_arch}")
       if ("${_base}" IN_LIST TGT_CUDA_ARCHS)
         list(REMOVE_ITEM _TGT_CUDA_ARCHS "${_base}")
         list(APPEND _CUDA_ARCHS "${_arch}")
diff --git a/csrc/quantization/w8a8/cutlass/c3x/scaled_mm_blockwise_sm100_fp8_dispatch.cuh b/csrc/quantization/w8a8/cutlass/c3x/scaled_mm_blockwise_sm100_fp8_dispatch.cuh
index dbf79a0651159..e7bb061ba0244 100644
--- a/csrc/quantization/w8a8/cutlass/c3x/scaled_mm_blockwise_sm100_fp8_dispatch.cuh
+++ b/csrc/quantization/w8a8/cutlass/c3x/scaled_mm_blockwise_sm100_fp8_dispatch.cuh
@@ -231,7 +231,7 @@ void cutlass_gemm_blockwise_sm100_fp8_dispatch(torch::Tensor& out,
       } else {
         cutlass_gemm_caller_blockwise<cutlass_3x_gemm_fp8_blockwise<
             OutType, 1, TILE_N, TILE_K, Shape<_64, Int<TILE_N>, Int<TILE_K>>,
-            Shape<_1, _1, _1>, cutlass::epilogue::NoSmemWarpSpecialized1Sm,
+            Shape<_1, _1, _1>, cutlass::epilogue::BlockwiseNoSmemWarpSpecialized1Sm,
             cutlass::gemm::KernelTmaWarpSpecializedBlockwise1SmSm100>>(
             out, a, b, a_scales, b_scales);
       }
@@ -245,7 +245,7 @@ void cutlass_gemm_blockwise_sm100_fp8_dispatch(torch::Tensor& out,
       } else {
         cutlass_gemm_caller_blockwise<cutlass_3x_gemm_fp8_blockwise<
             OutType, 1, TILE_N, TILE_K, Shape<_128, Int<TILE_N>, Int<TILE_K>>,
-            Shape<_1, _1, _1>, cutlass::epilogue::NoSmemWarpSpecialized1Sm,
+            Shape<_1, _1, _1>, cutlass::epilogue::BlockwiseNoSmemWarpSpecialized1Sm,
             cutlass::gemm::KernelTmaWarpSpecializedBlockwise1SmSm100>>(
             out, a, b, a_scales, b_scales);
       }
@@ -259,7 +259,7 @@ void cutlass_gemm_blockwise_sm100_fp8_dispatch(torch::Tensor& out,
       } else {
           cutlass_gemm_caller_blockwise<cutlass_3x_gemm_fp8_blockwise<
               OutType, 1, TILE_N, TILE_K, Shape<_256, Int<TILE_N>, Int<TILE_K>>,
-            Shape<_2, _1, _1>, cutlass::epilogue::NoSmemWarpSpecialized2Sm,
+            Shape<_2, _1, _1>, cutlass::epilogue::BlockwiseNoSmemWarpSpecialized2Sm,
             cutlass::gemm::KernelTmaWarpSpecializedBlockwise2SmSm100>>(
             out, a, b, a_scales, b_scales);
       }
@@ -271,10 +271,10 @@ void cutlass_gemm_blockwise_sm100_fp8_dispatch(torch::Tensor& out,
     // TMA epilogue isn't compatible with Swap A/B
     cutlass_gemm_caller_blockwise<cutlass_3x_gemm_fp8_blockwise<
         OutType, TILE_M, 1, TILE_K, Shape<Int<TILE_M>, Int<TILE_N>, Int<TILE_K>>,
-        Shape<_1, _1, _1>, cutlass::epilogue::NoSmemWarpSpecialized1Sm,
+        Shape<_1, _1, _1>, cutlass::epilogue::BlockwiseNoSmemWarpSpecialized1Sm,
         cutlass::gemm::KernelTmaWarpSpecializedBlockwise1SmSm100, true>>(
         out, a, b, a_scales, b_scales);
   }
 }
 
-}  // namespace vllm
+}  // namespace vllm
\ No newline at end of file
diff --git a/csrc/quantization/w8a8/cutlass/c3x/scaled_mm_sm100_fp8_dispatch.cuh b/csrc/quantization/w8a8/cutlass/c3x/scaled_mm_sm100_fp8_dispatch.cuh
index 24564efbd21be..f876b7d9acd87 100644
--- a/csrc/quantization/w8a8/cutlass/c3x/scaled_mm_sm100_fp8_dispatch.cuh
+++ b/csrc/quantization/w8a8/cutlass/c3x/scaled_mm_sm100_fp8_dispatch.cuh
@@ -133,4 +133,4 @@ void cutlass_scaled_mm_sm100_fp8_epilogue(torch::Tensor& out,
   }
 }
 
-}  // namespace vllm
\ No newline at end of file
+}  // namespace vllm
diff --git a/csrc/quantization/w8a8/cutlass/scaled_mm_entry.cu b/csrc/quantization/w8a8/cutlass/scaled_mm_entry.cu
index 84843ee6e0949..04b64a35da376 100644
--- a/csrc/quantization/w8a8/cutlass/scaled_mm_entry.cu
+++ b/csrc/quantization/w8a8/cutlass/scaled_mm_entry.cu
@@ -67,8 +67,9 @@ void cutlass_scaled_mm_sm100(torch::Tensor& c, torch::Tensor const& a,
                              std::optional<torch::Tensor> const& bias);
 #endif
 
-#if defined(ENABLE_SCALED_MM_SM90) && ENABLE_SCALED_MM_SM90 || \
-    defined(ENABLE_SCALED_MM_SM100) && ENABLE_SCALED_MM_SM100
+#if defined(ENABLE_SCALED_MM_SM90) && ENABLE_SCALED_MM_SM90 ||   \
+    defined(ENABLE_SCALED_MM_SM100) && ENABLE_SCALED_MM_SM100 || \
+    defined(ENABLE_SCALED_MM_SM120) && ENABLE_SCALED_MM_SM120
 void get_cutlass_moe_mm_data_caller(
     const torch::Tensor& topk_ids, torch::Tensor& expert_offsets,
     torch::Tensor& problem_sizes1, torch::Tensor& problem_sizes2,