diff --git a/requirements/rocm.txt b/requirements/rocm.txt
index 7038c9024c6b..c3bb65b70a0b 100644
--- a/requirements/rocm.txt
+++ b/requirements/rocm.txt
@@ -17,4 +17,4 @@ setuptools>=77.0.3,<80.0.0
 setuptools-scm>=8
 runai-model-streamer==0.11.0
 runai-model-streamer-s3==0.11.0
-conch-triton-kernels==1.2.1
+conch-triton-kernels==1.2.1
\ No newline at end of file
diff --git a/setup.py b/setup.py
index fa406b868c07..ca6e0a8592cc 100644
--- a/setup.py
+++ b/setup.py
@@ -695,6 +695,8 @@ setup(
         "video": [],  # Kept for backwards compatibility
         # FlashInfer should be updated together with the Dockerfile
         "flashinfer": ["flashinfer-python==0.2.12"],
+        # Optional deps for AMD FP4 quantization support
+        "petit-kernel": ["petit-kernel"],
     },
     cmdclass=cmdclass,
     package_data=package_data,
diff --git a/vllm/config/__init__.py b/vllm/config/__init__.py
index fbc4dd3989f5..6ce40626b3a8 100644
--- a/vllm/config/__init__.py
+++ b/vllm/config/__init__.py
@@ -1119,9 +1119,20 @@ class ModelConfig:
     def _verify_quantization(self) -> None:
         supported_quantization = me_quant.QUANTIZATION_METHODS
         optimized_quantization_methods = [
-            "fp8", "modelopt", "gptq_marlin_24", "gptq_marlin", "awq_marlin",
-            "fbgemm_fp8", "compressed-tensors", "experts_int8", "quark",
-            "modelopt_fp4", "bitblas", "gptq_bitblas", "inc"
+            "fp8",
+            "modelopt",
+            "gptq_marlin_24",
+            "gptq_marlin",
+            "awq_marlin",
+            "fbgemm_fp8",
+            "compressed-tensors",
+            "experts_int8",
+            "quark",
+            "modelopt_fp4",
+            "bitblas",
+            "gptq_bitblas",
+            "inc",
+            "petit_nvfp4",
         ]
         if self.quantization is not None:
             self.quantization = cast(me_quant.QuantizationMethods,
@@ -1153,6 +1164,7 @@ class ModelConfig:
                 "moe_wna16",
                 "modelopt",
                 "modelopt_fp4",
+                "petit_nvfp4",
             ]
             quantization_methods = [
                 q for q in supported_quantization if q not in overrides
diff --git a/vllm/model_executor/layers/linear.py b/vllm/model_executor/layers/linear.py
index 9b1ab7af0ac8..5725c841e529 100644
--- a/vllm/model_executor/layers/linear.py
+++ b/vllm/model_executor/layers/linear.py
@@ -52,6 +52,7 @@ WEIGHT_LOADER_V2_SUPPORTED = [
     "HQQMarlinMethod",
     "QuarkLinearMethod",
     "ModelOptNvFp4LinearMethod",
+    "PetitNvFp4LinearMethod",
 ]
 
 
diff --git a/vllm/model_executor/layers/quantization/__init__.py b/vllm/model_executor/layers/quantization/__init__.py
index ea51468422dc..d73fcf368f26 100644
--- a/vllm/model_executor/layers/quantization/__init__.py
+++ b/vllm/model_executor/layers/quantization/__init__.py
@@ -35,6 +35,7 @@ QuantizationMethods = Literal[
     "rtn",
     "inc",
     "mxfp4",
+    "petit_nvfp4",
 ]
 QUANTIZATION_METHODS: list[str] = list(get_args(QuantizationMethods))
 
@@ -108,6 +109,7 @@ def get_quantization_config(quantization: str) -> type[QuantizationConfig]:
     from .moe_wna16 import MoeWNA16Config
     from .mxfp4 import Mxfp4Config
     from .neuron_quant import NeuronQuantConfig
+    from .petit import PetitNvFp4Config
     from .ptpc_fp8 import PTPCFp8Config
     from .rtn import RTNConfig
     from .torchao import TorchAOConfig
@@ -142,6 +144,7 @@ def get_quantization_config(quantization: str) -> type[QuantizationConfig]:
         "rtn": RTNConfig,
         "inc": INCConfig,
         "mxfp4": Mxfp4Config,
+        "petit_nvfp4": PetitNvFp4Config,
     }
     # Update the `method_to_config` with customized quantization methods.
     method_to_config.update(_CUSTOMIZED_METHOD_TO_QUANT_CONFIG)
diff --git a/vllm/model_executor/layers/quantization/petit.py b/vllm/model_executor/layers/quantization/petit.py
new file mode 100644
index 000000000000..5b9fee69bb02
--- /dev/null
+++ b/vllm/model_executor/layers/quantization/petit.py
@@ -0,0 +1,306 @@
+# SPDX-License-Identifier: Apache-2.0
+# SPDX-FileCopyrightText: Copyright contributors to the vLLM project
+# Adapted from https://github.com/vllm-project/vllm/blob/main/vllm/model_executor/layers/quantization/modelopt.py
+
+from typing import Any, Optional
+
+import regex as re
+import torch
+from torch.nn.parameter import Parameter
+
+from vllm.logger import init_logger
+from vllm.model_executor.layers.linear import (LinearBase, LinearMethodBase,
+                                               UnquantizedLinearMethod)
+from vllm.model_executor.layers.quantization import QuantizationMethods
+from vllm.model_executor.layers.quantization.base_config import (
+    QuantizationConfig, QuantizeMethodBase)
+from vllm.model_executor.layers.quantization.kv_cache import BaseKVCacheMethod
+from vllm.model_executor.layers.quantization.utils.petit_utils import (
+    apply_petit_nvfp4_linear, prepare_nvfp4_layer_for_petit,
+    verify_petit_nvfp4_supported)
+from vllm.model_executor.layers.quantization.utils.quant_utils import (
+    is_layer_skipped)
+from vllm.model_executor.parameter import (ModelWeightParameter,
+                                           PerTensorScaleParameter)
+from vllm.platforms import current_platform
+
+# Initialize logger for the module
+logger = init_logger(__name__)
+
+
+# Configuration class to support the NVFP4 quantized model
+# generated by the ModelOpt quantization tool
+class PetitNvFp4Config(QuantizationConfig):
+    """Config class for Petit FP4."""
+
+    def __init__(
+        self,
+        is_checkpoint_nvfp4_serialized: bool = False,
+        kv_cache_quant_algo: Optional[str] = None,
+        group_size: Optional[int] = None,
+        exclude_modules: Optional[list[str]] = None,
+    ) -> None:
+        self._check_hardware_support()
+        self.is_checkpoint_nvfp4_serialized = is_checkpoint_nvfp4_serialized
+        if is_checkpoint_nvfp4_serialized:
+            logger.warning("Detected nvfp4 checkpoint. Please note that the "
+                           "format is experimental and subject to change.")
+        self.group_size = group_size
+        self.kv_cache_quant_algo = kv_cache_quant_algo
+        self.exclude_modules = exclude_modules
+
+    def _check_hardware_support(self) -> None:
+        """
+        Verifies that the current hardware is supported by the Petit backend.
+        This backend is specifically designed for AMD GPUs and is not
+        supported on the CUDA platform.
+        """
+        # This check ensures the code is NOT running on an NVIDIA GPU.
+        if current_platform.is_cuda():
+            raise ValueError(
+                "The 'petit' quantization backend is designed for AMD GPUs "
+                "and is not supported on the CUDA platform. For NVIDIA GPUs, "
+                "please use a different quantization method such as FP8, AWQ, "
+                "or GPTQ.")
+
+    @classmethod
+    def get_name(cls) -> QuantizationMethods:
+        return "petit_nvfp4"
+
+    @classmethod
+    def get_supported_act_dtypes(cls) -> list[torch.dtype]:
+        return [torch.bfloat16, torch.half]
+
+    @classmethod
+    def get_min_capability(cls) -> int:
+        # Petit supports the gfx90a and gfx942 GPUs
+        return 90
+
+    @classmethod
+    def get_config_filenames(cls) -> list[str]:
+        return ["hf_quant_config.json"]
+
+    @classmethod
+    def from_config(cls, config: dict[str, Any]) -> "PetitNvFp4Config":
+        qc = cls.get_from_keys(config, ["quantization"])
+
+        quant_method_raw = qc.get("quant_algo")
+        if not isinstance(quant_method_raw, str) or not quant_method_raw:
+            raise ValueError(
+                "Missing or invalid 'quant_algo' in quantization config.")
+        quant_method = quant_method_raw.upper()
+
+        group_size_raw = qc.get("group_size")
+        if not isinstance(group_size_raw, int):
+            raise ValueError(
+                "Missing or invalid 'group_size' (int) in hf_quant_config.json."
+            )
+        group_size = group_size_raw
+
+        verify_petit_nvfp4_supported(quant_method, group_size)
+
+        kv_cache_quant_algo_raw = qc.get("kv_cache_quant_algo") or "auto"
+        if not isinstance(kv_cache_quant_algo_raw, str):
+            raise ValueError(
+                "'kv_cache_quant_algo' must be a string if provided.")
+        kv_cache_quant_algo = kv_cache_quant_algo_raw
+
+        exclude_raw = qc.get("exclude_modules", [])
+        if exclude_raw is None:
+            exclude_modules: list[str] = []
+        elif isinstance(exclude_raw, list) and all(
+                isinstance(x, str) for x in exclude_raw):
+            exclude_modules = exclude_raw
+        else:
+            raise ValueError(
+                "'exclude_modules' must be a list[str] (or omitted).")
+
+        is_checkpoint_nvfp4_serialized = "NVFP4" in quant_method
+
+        return cls(
+            is_checkpoint_nvfp4_serialized=is_checkpoint_nvfp4_serialized,
+            kv_cache_quant_algo=kv_cache_quant_algo,
+            group_size=group_size,
+            exclude_modules=exclude_modules,
+        )
+
+    @classmethod
+    def override_quantization_method(
+            cls, hf_quant_cfg, user_quant) -> Optional[QuantizationMethods]:
+        if not current_platform.is_rocm():
+            return None
+
+        qc = hf_quant_cfg.get("quantization", hf_quant_cfg)
+        algo = (qc.get("quant_algo") or qc.get("quant_method") or "").upper()
+        if algo in ("NVFP4", "MODELOPT_FP4", "MODELOPT"):
+            return cls.get_name()  # "petit_nvfp4"
+        return None
+
+    @classmethod
+    def is_petit_nvfp4_compatible(cls, quant_config: dict[str, Any]) -> bool:
+        qc = quant_config.get("quantization", quant_config)
+        algo = (qc.get("quant_algo") or qc.get("quant_method") or "").upper()
+        return algo == "NVFP4"
+
+    def is_layer_excluded(self, prefix: str,
+                          exclude_modules: list[str]) -> bool:
+        for pattern in exclude_modules:
+            regex_str = pattern.replace(".", r"\.").replace("*", r".*")
+            if re.fullmatch(regex_str, prefix):
+                return True
+        return False
+
+    def get_quant_method(self, layer: torch.nn.Module,
+                         prefix: str) -> Optional["QuantizeMethodBase"]:
+        from vllm.attention.layer import Attention  # Avoid circular import
+
+        exclude = self.require_exclude_modules()
+
+        if isinstance(layer, LinearBase):
+            if is_layer_skipped(prefix, exclude) or self.is_layer_excluded(
+                    prefix, exclude):
+                return UnquantizedLinearMethod()
+            return PetitNvFp4LinearMethod(self)
+        elif isinstance(layer, Attention):
+            return PetitFp8KVCacheMethod(self)
+        return None
+
+    def get_scaled_act_names(self) -> list[str]:
+        return []
+
+    def require_group_size(self) -> int:
+        if self.group_size is None:
+            logger.warning("group_size not set; defaulting to 16 for NVFP4.")
+            return 16
+        return self.group_size
+
+    def require_kv_cache_quant_algo(self) -> str:
+        return self.kv_cache_quant_algo or "auto"
+
+    def require_exclude_modules(self) -> list[str]:
+        return list(self.exclude_modules or [])
+
+
+class PetitFp8KVCacheMethod(BaseKVCacheMethod):
+    """
+    Supports loading kv-cache scaling factors from FP8 checkpoints.
+    """
+
+    def __init__(self, quant_config: PetitNvFp4Config):
+        super().__init__(quant_config)
+
+
+class PetitNvFp4LinearMethod(LinearMethodBase):
+    """Linear method for NVFP4.
+    Supports loading NVFP4 checkpoints with the following structure:
+
+    |Tensor Name           | datatype      |  shape      |
+    |----------------------------------------------------|
+    |input_scale           | torch.float32 | scalar      |
+    |weight                | NVFP4(SE2M1)  | [1, X, y/2] |
+    |weight_scale          | FP8-E4M3      | [X, Y]      |
+    |weight_scale_2        | torch.float32 | scalar      |
+
+    The weights are quantized per block of 16 elements.
+    Args: quant_config: The ModelOpt quantization config.
+    """
+
+    def __init__(self, quant_config: PetitNvFp4Config):
+        self.quant_config = quant_config
+
+    def create_weights(
+        self,
+        layer: torch.nn.Module,
+        input_size_per_partition: int,
+        output_partition_sizes: list[int],
+        input_size: int,
+        output_size: int,
+        params_dtype: torch.dtype,
+        **extra_weight_attrs,
+    ):
+        del input_size, output_size
+        if not self.quant_config.is_checkpoint_nvfp4_serialized:
+            raise ValueError("NVFP4 quantization was selected, "
+                             " dynamic quantization is not supported.")
+
+        output_size_per_partition = sum(output_partition_sizes)
+        weight_loader = extra_weight_attrs.get("weight_loader")
+
+        layer.logical_widths = output_partition_sizes
+
+        layer.input_size_per_partition = input_size_per_partition
+        layer.output_size_per_partition = output_size_per_partition
+        if input_size_per_partition % 16 != 0:
+            raise ValueError("Unsupported model when in features size is "
+                             "not multiple of 16")
+
+        weight_dtype = (torch.float8_e4m3fn
+                        if self.quant_config.is_checkpoint_nvfp4_serialized
+                        else params_dtype)
+
+        weight = ModelWeightParameter(
+            data=torch.empty(
+                # 2 fp4 data is packed in one uint8 in the input dimension
+                output_size_per_partition,
+                input_size_per_partition // 2,
+                dtype=torch.uint8,
+            ),
+            input_dim=1,
+            output_dim=0,
+            weight_loader=weight_loader,
+        )
+        layer.register_parameter("weight", weight)
+
+        input_scale = PerTensorScaleParameter(
+            data=torch.empty(len(output_partition_sizes), dtype=torch.float32),
+            weight_loader=weight_loader,
+        )
+
+        layer.register_parameter("input_scale", input_scale)
+
+        weight_scale_2 = PerTensorScaleParameter(
+            data=torch.empty(len(output_partition_sizes), dtype=torch.float32),
+            weight_loader=weight_loader,
+        )
+        layer.register_parameter("weight_scale_2", weight_scale_2)
+
+        group_size = self.quant_config.require_group_size()
+        weight_scale = ModelWeightParameter(
+            data=torch.empty(
+                output_size_per_partition,
+                input_size_per_partition // group_size,
+                dtype=weight_dtype,
+            ),
+            input_dim=1,
+            output_dim=0,
+            weight_loader=weight_loader,
+        )
+
+        layer.register_parameter("weight_scale", weight_scale)
+
+    def process_weights_after_loading(self, layer: torch.nn.Module) -> None:
+        input_scale_2 = layer.input_scale.max().to(torch.float32)
+        weight_scale_2 = layer.weight_scale_2.max().to(torch.float32)
+        layer.input_scale = Parameter(input_scale_2, requires_grad=False)
+        layer.weight_scale_2 = Parameter(weight_scale_2, requires_grad=False)
+        layer.alpha = Parameter(layer.input_scale * layer.weight_scale_2,
+                                requires_grad=False)
+
+        prepare_nvfp4_layer_for_petit(layer)
+        del layer.input_scale
+
+    def apply(
+        self,
+        layer: torch.nn.Module,
+        x: torch.Tensor,
+        bias: Optional[torch.Tensor] = None,
+    ) -> torch.Tensor:
+        return apply_petit_nvfp4_linear(
+            input=x,
+            weight=layer.weight,
+            weight_scale=layer.weight_scale,
+            weight_scale_2=layer.weight_scale_2,
+            size_n=layer.output_size_per_partition,
+            size_k=layer.input_size_per_partition,
+            bias=bias,
+        )
diff --git a/vllm/model_executor/layers/quantization/utils/petit_utils.py b/vllm/model_executor/layers/quantization/utils/petit_utils.py
new file mode 100644
index 000000000000..00d3def1db81
--- /dev/null
+++ b/vllm/model_executor/layers/quantization/utils/petit_utils.py
@@ -0,0 +1,122 @@
+# SPDX-License-Identifier: Apache-2.0
+# SPDX-FileCopyrightText: Copyright contributors to the vLLM project
+from typing import TYPE_CHECKING, Optional
+
+import torch
+
+# TYPE_CHECKING is used for static type analysis to prevent circular imports.
+if TYPE_CHECKING:
+    from types import ModuleType
+
+# 1. Create a global variable as a placeholder for the module
+_petit_kernel: Optional["ModuleType"] = None
+
+_PETIT_INSTALL_MSG = ("Petit is not installed. Please install it with "
+                      "`pip install petit-kernel`.")
+
+
+def _import_petit_kernel() -> "ModuleType":
+    """
+    A helper function to handle the lazy import.
+    The first time this function is called, it will import the petit_kernel 
+    library and store it in the global _petit_kernel variable.
+    Subsequent calls will return the already-loaded module directly.
+    """
+    global _petit_kernel
+    if _petit_kernel is not None:
+        return _petit_kernel
+
+    try:
+        import petit_kernel
+        _petit_kernel = petit_kernel
+        return _petit_kernel
+    except ImportError:
+        # The 'from None' syntax prevents chaining the original ImportError,
+        # making the traceback cleaner.
+        raise ImportError(_PETIT_INSTALL_MSG) from None
+
+
+# The _require_petit function can now be a simple alias for consistency.
+_require_petit = _import_petit_kernel
+
+
+def _check_petit_nvfp4_supported(
+        quant_method: str,
+        group_size: Optional[int]) -> tuple[bool, Optional[str]]:
+    if quant_method != "NVFP4":
+        return (
+            False,
+            ("Petit currently only supports: NVFP4 quantizations in sglang. "
+             "Please check the `hf_quant_config.json` file for your model's "
+             "quant configuration."),
+        )
+    if group_size is not None and group_size != 16:
+        return (
+            False,
+            "Petit currently only supports: group_size=16 quantizations.",
+        )
+    return (True, None)
+
+
+def verify_petit_nvfp4_supported(quant_method: str,
+                                 group_size: Optional[int]) -> None:
+    supported, error_msg = _check_petit_nvfp4_supported(
+        quant_method, group_size)
+    if not supported:
+        assert error_msg is not None
+        raise ValueError(error_msg)
+
+
+def prepare_nvfp4_layer_for_petit(layer: torch.nn.Module) -> None:
+    # 2. Call _import_petit_kernel() to trigger (or get) the import.
+    petit_kernel = _import_petit_kernel()
+
+    # Repack weights to petit format
+    part_size_n = layer.output_size_per_partition
+    part_size_k = layer.input_size_per_partition
+    qweight = layer.weight.view(torch.int32).contiguous()
+
+    # 3. Call functions through the imported module variable.
+    petit_qweight = petit_kernel.repack_nvfp4(qweight,
+                                              size_n=part_size_n,
+                                              size_k=part_size_k)
+    layer.weight = torch.nn.Parameter(petit_qweight, requires_grad=False)
+
+    # Permute scales
+    weight_scale = petit_kernel.process_nvfp4_scales(scales=layer.weight_scale,
+                                                     size_k=part_size_k,
+                                                     size_n=part_size_n)
+    layer.weight_scale = torch.nn.Parameter(weight_scale, requires_grad=False)
+
+
+def apply_petit_nvfp4_linear(
+    input: torch.Tensor,
+    weight: torch.Tensor,
+    weight_scale: torch.Tensor,
+    weight_scale_2: torch.Tensor,
+    size_n: int,
+    size_k: int,
+    bias: Optional[torch.Tensor] = None,
+) -> torch.Tensor:
+    # Trigger (or get) the import here as well.
+    petit_kernel = _import_petit_kernel()
+
+    reshaped_x = input.reshape(-1, input.shape[-1])
+    out_shape = input.shape[:-1] + (size_n, )
+
+    # TODO: Use auto-tuning to find the performant solution_id
+    # Call the function via the module variable.
+    output = petit_kernel.mul_nvfp4_a16(
+        a=reshaped_x,
+        b=weight,
+        s=weight_scale,
+        global_scale=weight_scale_2,
+        size_m=reshaped_x.size(0),
+        size_n=size_n,
+        size_k=size_k,
+        solution_id=-1,
+    )
+    if bias is not None:
+        output.add_(bias)  # In-place add
+
+    return output.reshape(out_shape)
diff --git a/vllm/platforms/rocm.py b/vllm/platforms/rocm.py
index 317bc401a799..323ec591c50a 100644
--- a/vllm/platforms/rocm.py
+++ b/vllm/platforms/rocm.py
@@ -171,7 +171,7 @@ class RocmPlatform(Platform):
 
     supported_quantization: list[str] = [
         "awq", "gptq", "fp8", "compressed-tensors", "fbgemm_fp8", "gguf",
-        "quark", "ptpc_fp8", "mxfp4"
+        "quark", "ptpc_fp8", "mxfp4", "petit_nvfp4"
     ]
 
     @classmethod